Preparation of New Sargassum fusiforme Polysaccharide Long-Chain Alkyl Group Nanomicelles and Their Antiviral Properties against ALV-J

doi:10.3390/molecules26113265

IOCAS-IR > 实验海洋生物学重点实验室

	Preparation of New Sargassum fusiforme Polysaccharide Long-Chain Alkyl Group Nanomicelles and Their Antiviral Properties against ALV-J
	Sun, Yuhao1,2,3 ; Chen, Xiaolin 1,2,3; Liu, Hong 1,2,3; Liu, Song 1,2,3; Yu, Huahua1,2,3 ; Wang, Xueqin 1,2,3; Qin, Yukun1,2,3 ; Li, Pengcheng1,2,3
	2021-06-01
发表期刊	MOLECULES
卷号	26 期号:11 页码:15
通讯作者	Li, Pengcheng(pcli@qdio.ac.cn)
摘要	Avian leukosis virus subgroup J (ALV-J) is an immunosuppressive virus which has caused heavy losses to the poultry breeding industry. Currently, there is no effective medicine to treat this virus. In our previous experiments, the low-molecular-weight Sargassum fusiforme polysaccharide (SFP) was proven to possess antiviral activity against ALV-J, but its function was limited to the virus adsorption stage. In order to improve the antiviral activity of the SFP, in this study, three new SFP long-chain alkyl group nanomicelles (SFP-C12M, SFP-C14M and SFP-C16M) were prepared. The nanomicelles were characterized according to their physical and chemical properties. The nanomicelles were characterized by particle size, zeta potential, polydispersity index, critical micelle concentration and morphology. The results showed the particle sizes of the three nanomicelles were all approximately 200 nm and SFP-C14M and SFP-C16M were more stable than SFP-C12M. The newly prepared nanomicelles exhibited a better anti-ALV-J activity than the SFP, with SFP-C16M exhibiting the best antiviral effects in both the virus adsorption stage and the replication stage. The results of the giant unilamellar vesicle exposure experiment demonstrated that the new virucidal effect of the nanomicelles might be caused by damage to the phospholipid membrane of ALV-J. This study provides a potential idea for ALV-J prevention and development of other antiviral drugs.
关键词	Sargassum fusiforme polysaccharide long-chain alkyl group antiviral activity ALV-J
DOI	10.3390/molecules26113265
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2018YFD0901104] ; Shandong Province Key Research and Development Project[2018GHY115008] ; Shandong Province Key Research and Development Project[2017GHY215008] ; Qingdao Science and Technology Project[17-3-3-60-nsh]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000660362800001
出版者	MDPI
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/176832
专题	实验海洋生物学重点实验室
通讯作者	Li, Pengcheng
作者单位	1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, CAS, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
第一作者单位	中国科学院海洋大科学研究中心
通讯作者单位	中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Sun, Yuhao,Chen, Xiaolin,Liu, Hong,et al. Preparation of New Sargassum fusiforme Polysaccharide Long-Chain Alkyl Group Nanomicelles and Their Antiviral Properties against ALV-J[J]. MOLECULES,2021,26(11):15.
APA	Sun, Yuhao.,Chen, Xiaolin.,Liu, Hong.,Liu, Song.,Yu, Huahua.,...&Li, Pengcheng.(2021).Preparation of New Sargassum fusiforme Polysaccharide Long-Chain Alkyl Group Nanomicelles and Their Antiviral Properties against ALV-J.MOLECULES,26(11),15.
MLA	Sun, Yuhao,et al."Preparation of New Sargassum fusiforme Polysaccharide Long-Chain Alkyl Group Nanomicelles and Their Antiviral Properties against ALV-J".MOLECULES 26.11(2021):15.

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