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Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069
Song, Fuhang1; Yang, Na2,3; Khalil, Zeinab G.4; Salim, Angela A.4; Han, Jiahui5; Bernhardt, Paul, V6; Lin, Rui5; Xu, Xiuli5; Capon, Robert J.4
2021-10-27
Source PublicationCHEMISTRY & BIODIVERSITY
ISSN1612-1872
Pages7
Corresponding AuthorXu, Xiuli(xuxl@cugb.edu.cn) ; Capon, Robert J.(r.capon@uq.edu.au)
AbstractChemical investigation on a Streptomyces sp. strain MS180069 isolated from a sediment sample collected from the South China Sea, yielded the new benzo[f]isoindole-dione alkaloid, bhimamycin J (1). The structure was determined by extensive spectroscopic analysis, including HRMS, 1D, 2D NMR, and X-ray diffraction techniques. A molecular docking study revealed 1 as a new molecular motif that binds with human angiotensin converting enzyme2 (ACE2), recently described as the cell surface receptor responsible for uptake of 2019-CoV-2. Using enzyme assays we confirm that 1 inhibits human ACE2 79.7 % at 25 mu g/mL.
Keywordmarine-derived actinomycete bhimamycin J SARS-CoV-2 molecular docking angiotensin converting enzyme2
DOI10.1002/cbdv.202100674
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFC0311000] ; Key Lab of Marine Bioactive Substance and Modern Analytical Technique, SOA[MBSMAT-2019-06] ; National Natural Science Foundation of China[81973204] ; Research Foundation for Advanced Talents of Beijing Technology and Business University[19008020158]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000711551900001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/176750
Collection实验海洋生物学重点实验室
Corresponding AuthorXu, Xiuli; Capon, Robert J.
Affiliation1.Beijing Technol & Business Univ, Sch Light Ind, Beijing 100048, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
4.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
5.China Univ Geosci, Sch Ocean Sci, Beijing 100083, Peoples R China
6.Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia
Recommended Citation
GB/T 7714
Song, Fuhang,Yang, Na,Khalil, Zeinab G.,et al. Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069[J]. CHEMISTRY & BIODIVERSITY,2021:7.
APA Song, Fuhang.,Yang, Na.,Khalil, Zeinab G..,Salim, Angela A..,Han, Jiahui.,...&Capon, Robert J..(2021).Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069.CHEMISTRY & BIODIVERSITY,7.
MLA Song, Fuhang,et al."Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069".CHEMISTRY & BIODIVERSITY (2021):7.
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