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CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense
Li, Xue-peng1; Chen, Guan-yu1; Jin, Qiu1; Lou, Fang-rui1; Liu, Bing-jian3; Zhang, Jian1; Feng, Ji-xing1; Chen, Tian-tian2
2021-12-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume192Pages:1021-1028
Corresponding AuthorLi, Xue-peng(lixuepeng14@mails.ucas.ac.cn) ; Chen, Tian-tian(chentian0819@163.com)
AbstractInterleukin (IL)-11 is a multifunctional cytokine belonging to the IL-6 family, which plays essential roles in immune response. However, much less is known about the immunological functions of IL-11 in teleost. In this study, we investigated the immune properties of a teleost IL-11 homologue (CsIL-11) from tongue sole Cynoglossus semilaevis. CsIL-11 possesses four conserved alpha-helices and conserved CsIL-11 receptor binding residues L86 and R187, and shares 23.3%-80.1% identities with other IL-11 homologues. CsIL-11 expression was constitutive in tissues, with most abundant in blood and least abundant in spleen, and upregulated by bacterial challenge in blood, spleen, and head kidney. Recombinant CsIL-11 (rCsIL-11) in the native form of monomer, could bind to peripheral blood leukocytes (PBLs) membrane and enhance the activation and phagocytosis of PBLs. When administered in vivo, rCsIL-11 could markedly promote the host to defend against microbial infection. Overall, our findings show that CsIL-11 plays a pivotal role in regulating PBLs phagocytosis and antibacterial immunity.
KeywordInterleukin-11 Cynoglossus semilaevis Peripheral blood leukocytes Phagocytosis Antibacterial immunity
DOI10.1016/j.ijbiomac.2021.10.080
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000710454100007
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/176732
Collection海洋生态与环境科学重点实验室
Corresponding AuthorLi, Xue-peng; Chen, Tian-tian
Affiliation1.Yantai Univ, Sch Ocean, Yantai, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
3.Zhejiang Ocean Univ, Marine Sci & Technol Coll, Zhoushan, Peoples R China
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
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Li, Xue-peng,Chen, Guan-yu,Jin, Qiu,et al. CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,192:1021-1028.
APA Li, Xue-peng.,Chen, Guan-yu.,Jin, Qiu.,Lou, Fang-rui.,Liu, Bing-jian.,...&Chen, Tian-tian.(2021).CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,192,1021-1028.
MLA Li, Xue-peng,et al."CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 192(2021):1021-1028.
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