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Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition
Wu, Ning1,3,5; Li, Zhi1,2,4; Wang, Jing1,2; Geng, Lihua1,2; Yue, Yang1,2; Deng, Zhenzhen1,2,4; Wang, Qingchi1,2,4; Zhang, Quanbin1,2,4
2021-12-01
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume273Pages:10
Corresponding AuthorWu, Ning(wuning@qdio.ac.cn) ; Zhang, Quanbin(qbzhang@qdio.ac.cn)
AbstractDiffuse alveolar injury and pulmonary fibrosis (PF) are the main causes of death of Covid-19 cases. In this study a low molecular weight fucoidan (LMWF) with unique structural was obtained from Laminaria japonica, and its antiPF and anti-epithelial-mesenchymal transition (EMT) bioactivity were investigated both in vivo and in vitro. After LWMF treatment the fibrosis and inflammatory factors stimulated by Bleomycin (BLM) were in lung tissue. Immunohistochemical and Western-blot results found the expression of COL2A1, beta-catenin, TGF-beta, TNF-alpha and IL-6 were declined in mice lung tissue. Besides, the phosphorylation of PI3K and Akt were inhibited by LMWF. In addition, the progression of EMT induced by TGF-beta 1 was inhibited by LMWF through down-regulated both TGF-beta/Smad and PI3K/AKT signaling pathways. These data indicate that unique LMWF can protect the lung from fibrosis by weakening the process of inflammation and EMT, and it is a promising therapeutic option for the treatment of PF.
KeywordFucoidans COVID-19 Pulmonary fibrosis Epithelial-mesenchymal transition TGF-beta PI3K/AKT pathway
DOI10.1016/j.carbpol.2021.118567
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2019YFD0900705] ; Nantong Science and Technology program[MS12021037] ; Special Open Fund of Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology[OF2020NO02]
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000704364500005
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/176619
Collection实验海洋生物学重点实验室
Corresponding AuthorWu, Ning; Zhang, Quanbin
Affiliation1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Nantong Zhongke Marine Sci & Technol Res & Dev Ct, Nantong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wu, Ning,Li, Zhi,Wang, Jing,et al. Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition[J]. CARBOHYDRATE POLYMERS,2021,273:10.
APA Wu, Ning.,Li, Zhi.,Wang, Jing.,Geng, Lihua.,Yue, Yang.,...&Zhang, Quanbin.(2021).Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition.CARBOHYDRATE POLYMERS,273,10.
MLA Wu, Ning,et al."Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition".CARBOHYDRATE POLYMERS 273(2021):10.
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