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Exogenous sodium fumarate enhances astaxanthin accumulation in Haematococcus pluvialis by enhancing the respiratory metabolic pathway
Yu, Wenjie1,2,3; Zhang, Litao1,2; Zhao, Jing1,2,4; Liu, Jianguo1,2
2021-12-01
Source PublicationBIORESOURCE TECHNOLOGY
ISSN0960-8524
Volume341Pages:9
Corresponding AuthorLiu, Jianguo(jgliu@qdio.ac.cn)
AbstractImprovement of astaxanthin yield is a continuing objective in Haematococcus pluvialis cultivation. In this study, a new strategy combining exogenous sodium fumarate (SF) with nitrogen deficiency was demonstrated to promote astaxanthin accumulation in H. pluvialis. SF significantly accelerated astaxanthin synthesis over cell growth. Notably, under nitrogen deficiency, 10 mM SF increased the cellular astaxanthin content by 1.75-fold and 1.47 fold on day 7 and 12, respectively. Further studies indicated that SF increased the level of respiratory metabolites in the Embden-Meyerhof-Parnas pathway, tricarboxylic acid cycle and pentose phosphate pathway. An enhanced substrate pool due to the acceleration of respiratory metabolic pathways directly induced astaxanthin synthesis. Meanwhile, the accumulation of C18:1, C18:2 and C18:3 fatty acids enhanced astaxanthin synthesis indirectly by promoting the process of esterification. This study not only helps to elucidate the role of respiratory metabolic pathways in astaxanthin synthesis but also provides a new effective technique to improve astaxanthin production.
KeywordAstaxanthin Haematococcus pluvialis Sodium fumarate Respiratory metabolic pathway Nitrogen deficiency
DOI10.1016/j.biortech.2021.125788
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2018YFE0107200] ; National Natural Science Foundation of China[31872588] ; National Natural Science Foundation of China[U1706209] ; Shandong Provincial Natural Science Foundation, China[ZR2019BC057]
WOS Research AreaAgriculture ; Biotechnology & Applied Microbiology ; Energy & Fuels
WOS SubjectAgricultural Engineering ; Biotechnology & Applied Microbiology ; Energy & Fuels
WOS IDWOS:000694798100003
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/176419
Collection实验海洋生物学重点实验室
Corresponding AuthorLiu, Jianguo
Affiliation1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Peoples R China
First Author AffilicationCenter for Ocean Mega-Science, Chinese Academy of Sciences
Corresponding Author AffilicationCenter for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yu, Wenjie,Zhang, Litao,Zhao, Jing,et al. Exogenous sodium fumarate enhances astaxanthin accumulation in Haematococcus pluvialis by enhancing the respiratory metabolic pathway[J]. BIORESOURCE TECHNOLOGY,2021,341:9.
APA Yu, Wenjie,Zhang, Litao,Zhao, Jing,&Liu, Jianguo.(2021).Exogenous sodium fumarate enhances astaxanthin accumulation in Haematococcus pluvialis by enhancing the respiratory metabolic pathway.BIORESOURCE TECHNOLOGY,341,9.
MLA Yu, Wenjie,et al."Exogenous sodium fumarate enhances astaxanthin accumulation in Haematococcus pluvialis by enhancing the respiratory metabolic pathway".BIORESOURCE TECHNOLOGY 341(2021):9.
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