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Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512
Chi, Lu-Ping1,2,3; Li, Xiao-Ming1,2; Wan, Yu-Peng1; Li, Yan-He1,2,3; Li, Xin1,2; Wang, Bin-Gui1,2,4
2021-09-16
Source PublicationCHEMISTRY & BIODIVERSITY
ISSN1612-1872
Pages6
Corresponding AuthorLi, Xin(lixin@qdio.ac.cn) ; Wang, Bin-Gui(wangbg@nns.qdio.ac.cn)
AbstractTwo new phenol derivatives, namely insphenol A (1) and acetylpeniciphenol (2), along with seven known analogs (3-9), were isolated from the deep-sea cold seep-derived fungus, Aspergillus insuetus SD-512. The structures of 1 and 2 were established by extensive interpretation of NMR and mass spectroscopic data. The absolute configuration of 1 was determined by the combination of coupling constant analysis and acid hydrolysis. Among the isolated compounds, insphenol A (1) represents the first example of isopentenyl phenol derivative with a unique 1-glycosylation from the species Aspergillus insuetus. The isolated new compounds were evaluated for antibacterial activities against six human or aquatic pathogens, while compound 2 exhibited inhibitory effect against Edwardsiella tarda, Vibrio alginolyticus, and V. vulnificus, with MIC values of 4, 8, and 8 mu g/mL, respectively.
KeywordAspergillus insuetus cold seep-derived fungus marine natural products antibacterial activity
DOI10.1002/cbdv.202100512
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFC0310800] ; National Natural Science Foundation of China[42076090] ; National Natural Science Foundation of China[U2006203] ; Shandong Provincial Natural Science Foundation[ZR2019ZD18] ; Basic Applied Research program of Qingdao[19-6-2-40-cg] ; Senior User Project of RV KEXUE[KEXUE2020GZ02] ; Center for Ocean Mega-Science, Chinese Academy of Sciences ; Taishan Scholar Project from Shandong Province[ts201511060]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000696224300001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/176389
Collection实验海洋生物学重点实验室
Corresponding AuthorLi, Xin; Wang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Yuquan Rd 19 A, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Chi, Lu-Ping,Li, Xiao-Ming,Wan, Yu-Peng,et al. Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512[J]. CHEMISTRY & BIODIVERSITY,2021:6.
APA Chi, Lu-Ping,Li, Xiao-Ming,Wan, Yu-Peng,Li, Yan-He,Li, Xin,&Wang, Bin-Gui.(2021).Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512.CHEMISTRY & BIODIVERSITY,6.
MLA Chi, Lu-Ping,et al."Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512".CHEMISTRY & BIODIVERSITY (2021):6.
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