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Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet
Deng, Zhenzhen1,2,3; Wu, Ning1; Wang, Jing1,2; Zhang, Quanbin1,2
2021-10-01
Source PublicationJOURNAL OF FUNCTIONAL FOODS
ISSN1756-4646
Volume85Pages:11
Corresponding AuthorWang, Jing(jingwang@qdio.ac.cn) ; Zhang, Quanbin(qbzhang@qdio.ac.cn)
AbstractMetabolic syndrome (MetS) is a pathological state of multiple metabolic abnormalities. Dietary fibers (DFs) has been widely concerned about its positive role in MetS. Different from the DFs of terrestrial plants, the DFs of seaweeds has unique composition and structural characteristics. The aim of this study is to investigate the composition and microstructures of DF derived from Saccharina japonica, and its positive effects on MetS mice induced by high fat diet (HFD). We extracted DF from S. japonica (DFSJ). DFSJ has a high proportion of soluble dietary fiber (SDF) and it shows good water holding capacity (11.34 +/- 1.63 g/g) and swelling property (32.9 +/- 2.52 mL/g). Supplementing DFSJ can significantly improve insulin resistance (IR), dyslipidemia in HFD mice. Besides, DFSJ can reduce inflammatory factors (TNF-alpha, MCP-1 and IL-6), improve the hepatic oxidative stress and protect visceral organs from the injury of HFD. Finally, 16S rDNA high-throughput sequencing was used to further analyze the profile changes of gut microbiota. The results indicated that supplementing DFSJ can effectively ameliorate gut microbiota dysbiosis. In particular, DFSJ can increase the relative abundance of some beneficial bacteria, such as Bifidobacterium, Turicibacter and Akkermansia. Our results indicated that DFSJ has a comprehensive regulatory effect on MetS, and it is involved in various regulatory pathways, such as antioxidant, anti-inflammatory, hypoglycemic and hypolipidemic pathways in HFD-induced MetS mice. Our results reveal the great potential of DFSJ as an effective regulator on various metabolic abnormalities of MetS.
KeywordDietary fiber Insulin resistance Metabolic syndrome Gut microbiota
DOI10.1016/j.jff.2021.104642
Indexed BySCI
Language英语
Funding ProjectNational Key RD Plan of China[2018YFD0901104] ; Special Open Fund of Laboratory for Marine Biology and Biotechnology, Qingdao Pilot National Laboratory for Marine Science and Technology[OF2020NO02] ; Major Scientific & Engineering Projects of Innovation in Shandong Province[2019JZZY010818] ; K.C. Wong Education Foundation, CAS
WOS Research AreaFood Science & Technology ; Nutrition & Dietetics
WOS SubjectFood Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000686899700006
PublisherELSEVIER
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/176240
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Jing; Zhang, Quanbin
Affiliation1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Deng, Zhenzhen,Wu, Ning,Wang, Jing,et al. Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet[J]. JOURNAL OF FUNCTIONAL FOODS,2021,85:11.
APA Deng, Zhenzhen,Wu, Ning,Wang, Jing,&Zhang, Quanbin.(2021).Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet.JOURNAL OF FUNCTIONAL FOODS,85,11.
MLA Deng, Zhenzhen,et al."Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet".JOURNAL OF FUNCTIONAL FOODS 85(2021):11.
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