The Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance

doi:10.1038/s41421-021-00286-x

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	The Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance
	Huang, Chuying 1,2; Ying, Hongqin 3; Yang, Xibiao 4; Gao, Yuan 5; Li, Tuo 1,2; Wu, Bo 1,2; Ren, Meng 6,7; Zhang, Zixiong 1,2; Ding, Jun 1,2; Gao, Jianhua 8; Wen, Dan 9; Ye, Xingzhi 8; Liu, Ling 10; Wang, Huan 10; Sun, Guogen 1,2; Zou, Yi 1,2; Chen, Nansheng 11,12; Wang, Li 1,2
	2021-08-10
发表期刊	CELL DISCOVERY
卷号	7 期号:1 页码:14
通讯作者	Huang, Chuying(huangchuying2008@126.com)
摘要	Cardamine enshiensis is a well-known selenium (Se)-hyperaccumulating plant. Se is an essential trace element associated with many health benefits. Despite its critical importance, genomic information of this species is limited. Here, we report a chromosome-level genome assembly of C. enshiensis, which consists of 443.4 Mb in 16 chromosomes with a scaffold N50 of 24 Mb. To elucidate the mechanism of Se tolerance and hyperaccumulation in C. enshiensis, we generated and analyzed a dataset encompassing genomes, transcriptomes, and metabolomes. The results reveal that flavonoid, glutathione, and lignin biosynthetic pathways may play important roles in protecting C. enshiensis from stress induced by Se. Hi-C analysis of chromatin interaction patterns showed that the chromatin of C. enshiensis is partitioned into A and B compartments, and strong interactions between the two telomeres of each chromosome were correlated with histone modifications, epigenetic markers, DNA methylation, and RNA abundance. Se supplementation could affect the 3D chromatin architecture of C. enshiensis at the compartment level. Genes with compartment changes after Se treatment were involved in selenocompound metabolism, and genes in regions with topologically associated domain insulation participated in cellular responses to Se, Se binding, and flavonoid biosynthesis. This multiomics research provides molecular insight into the mechanism underlying Se tolerance and hyperaccumulation in C. enshiensis.
DOI	10.1038/s41421-021-00286-x
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81660503]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000685106500002
出版者	SPRINGERNATURE
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/176032
专题	中国科学院海洋研究所
通讯作者	Huang, Chuying
作者单位	1.Hubei Minzu Univ Affiliated Enshi Clin, Med Sch, Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Enshi, Hubei, Peoples R China 2.Hubei Selenium & Human Hlth Inst, Enshi, Hubei, Peoples R China 3.Enshi Autonomous Prefecture Acad Agr Sci, Hubei Selenium Ind Technol Res Inst, Enshi, Hubei, Peoples R China 4.Sichuan Univ, West China Hosp, Dept Radiol, Chengdu, Sichuan, Peoples R China 5.Univ Gothenburg, Dept Chem & Mol Biol, SE-40530 Gothenburg, Sweden 6.East China Normal Univ, Ctr Bioinformat & Computat Biol, Sch Life Sci, Shanghai, Peoples R China 7.East China Normal Univ, Inst Biomed Sci, Sch Life Sci, Shanghai, Peoples R China 8.Enshi Autonomous Prefecture Acad Agr Sci, South China Potato Res Ctr, Enshi, Hubei, Peoples R China 9.Bur Agr & Rural Affairs Enshi Tujia & Miao Autono, Enshi, Hubei, Peoples R China 10.Wuhan Frasergen Bioinformat Co Ltd, Wuhan, Hubei, Peoples R China 11.Chinese Acad Sci, Inst Oceanol, Qingdao, Shandong, Peoples R China 12.Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC, Canada
推荐引用方式 GB/T 7714	Huang, Chuying,Ying, Hongqin,Yang, Xibiao,et al. The Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance[J]. CELL DISCOVERY,2021,7(1):14.
APA	Huang, Chuying.,Ying, Hongqin.,Yang, Xibiao.,Gao, Yuan.,Li, Tuo.,...&Wang, Li.(2021).The Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance.CELL DISCOVERY,7(1),14.
MLA	Huang, Chuying,et al."The Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance".CELL DISCOVERY 7.1(2021):14.

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