Uncommon N-Methoxyindolediketopiperazines from Acrostalagmus luteoalbus, a Marine Algal Isolate of Endophytic Fungus

doi:10.1002/cjoc.202100368

IOCAS-IR > 实验海洋生物学重点实验室

	Uncommon N-Methoxyindolediketopiperazines from Acrostalagmus luteoalbus, a Marine Algal Isolate of Endophytic Fungus
	Cao, Jin 1,2,3; Li, Xiao-Ming 1,2,3; Li, Xin1,2,3 ; Li, Hong-Lei1,2,3 ; Konuklugil, Belma 4; Wang, Bin-Gui1,2,3,5
	2021-08-09
发表期刊	CHINESE JOURNAL OF CHEMISTRY
ISSN	1001-604X
页码	7
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
摘要	Main observation and conclusion Four new N-methoxyindolediketopiperazines (acrozines D-G, 1-4) and six known congeners (5-10) were purified from the organic extract of Acrostalagmus luteoalbus TK-43, which was a marine algal-derived fungus obtained from Codium fragile. Their structures were determined by interpretation of NMR and mass spectroscopic data. The structures of compounds 1, 2, and 4 including their absolute configurations were confirmed by single-crystal X-ray diffraction, while the absolute configuration of compound 3 was elucidated by comparative analysis of ECD and TDDFT-ECD calculations. Compounds 1-4, with a unique methoxy substitution at N-2, were rarely discovered among indolediketopiperazine alkaloids. All these compounds were evaluated for antimicrobial activities against human- and aquatic-pathogenic bacteria and plant-related pathogenic fungi, with compounds 5 and 7 exhibiting potent activity against Edwardsiella icataluri (MIC = 3 and 5 mu mol/L, respectively), while compound 9 displayed a broad spectrum of antibacterial activities. The four new compounds were further tested for anti-acetylcholinesterase (AChE) properties, and compound 3 exhibited inhibitory activity with IC50 value of 8.4 mu mol/L.
关键词	Marine alga Endophytic fungus Acrostalagmus luteoalbus Natural products Biological activity
DOI	10.1002/cjoc.202100368
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81673351] ; European Commission under the program Marie Curie Actions-International Research Staff Exchange Scheme (IRSES)[PIRSES-GA-2011-295226] ; Taishan Scholar Project from Shandong Province of China[ts201511060]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000682980700001
出版者	WILEY-V C H VERLAG GMBH
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/175951
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China 2.Chinese Acad Sci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China 4.Univ Ankara, Fac Pharm, Emniyet Mah Degol Cd 4, TR-06560 Ankara, Turkey 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Cao, Jin,Li, Xiao-Ming,Li, Xin,et al. Uncommon N-Methoxyindolediketopiperazines from Acrostalagmus luteoalbus, a Marine Algal Isolate of Endophytic Fungus[J]. CHINESE JOURNAL OF CHEMISTRY,2021:7.
APA	Cao, Jin,Li, Xiao-Ming,Li, Xin,Li, Hong-Lei,Konuklugil, Belma,&Wang, Bin-Gui.(2021).Uncommon N-Methoxyindolediketopiperazines from Acrostalagmus luteoalbus, a Marine Algal Isolate of Endophytic Fungus.CHINESE JOURNAL OF CHEMISTRY,7.
MLA	Cao, Jin,et al."Uncommon N-Methoxyindolediketopiperazines from Acrostalagmus luteoalbus, a Marine Algal Isolate of Endophytic Fungus".CHINESE JOURNAL OF CHEMISTRY (2021):7.

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