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Uncommon N-Methoxyindolediketopiperazines from Acrostalagmus luteoalbus, a Marine Algal Isolate of Endophytic Fungus
Cao, Jin1,2,3; Li, Xiao-Ming1,2,3; Li, Xin1,2,3; Li, Hong-Lei1,2,3; Konuklugil, Belma4; Wang, Bin-Gui1,2,3,5
2021-08-09
Source PublicationCHINESE JOURNAL OF CHEMISTRY
ISSN1001-604X
Pages7
Corresponding AuthorWang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractMain observation and conclusion Four new N-methoxyindolediketopiperazines (acrozines D-G, 1-4) and six known congeners (5-10) were purified from the organic extract of Acrostalagmus luteoalbus TK-43, which was a marine algal-derived fungus obtained from Codium fragile. Their structures were determined by interpretation of NMR and mass spectroscopic data. The structures of compounds 1, 2, and 4 including their absolute configurations were confirmed by single-crystal X-ray diffraction, while the absolute configuration of compound 3 was elucidated by comparative analysis of ECD and TDDFT-ECD calculations. Compounds 1-4, with a unique methoxy substitution at N-2, were rarely discovered among indolediketopiperazine alkaloids. All these compounds were evaluated for antimicrobial activities against human- and aquatic-pathogenic bacteria and plant-related pathogenic fungi, with compounds 5 and 7 exhibiting potent activity against Edwardsiella icataluri (MIC = 3 and 5 mu mol/L, respectively), while compound 9 displayed a broad spectrum of antibacterial activities. The four new compounds were further tested for anti-acetylcholinesterase (AChE) properties, and compound 3 exhibited inhibitory activity with IC50 value of 8.4 mu mol/L.
KeywordMarine alga Endophytic fungus Acrostalagmus luteoalbus Natural products Biological activity
DOI10.1002/cjoc.202100368
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81673351] ; European Commission under the program Marie Curie Actions-International Research Staff Exchange Scheme (IRSES)[PIRSES-GA-2011-295226] ; Taishan Scholar Project from Shandong Province of China[ts201511060]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000682980700001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/175951
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
2.Chinese Acad Sci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China
4.Univ Ankara, Fac Pharm, Emniyet Mah Degol Cd 4, TR-06560 Ankara, Turkey
5.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Cao, Jin,Li, Xiao-Ming,Li, Xin,et al. Uncommon N-Methoxyindolediketopiperazines from Acrostalagmus luteoalbus, a Marine Algal Isolate of Endophytic Fungus[J]. CHINESE JOURNAL OF CHEMISTRY,2021:7.
APA Cao, Jin,Li, Xiao-Ming,Li, Xin,Li, Hong-Lei,Konuklugil, Belma,&Wang, Bin-Gui.(2021).Uncommon N-Methoxyindolediketopiperazines from Acrostalagmus luteoalbus, a Marine Algal Isolate of Endophytic Fungus.CHINESE JOURNAL OF CHEMISTRY,7.
MLA Cao, Jin,et al."Uncommon N-Methoxyindolediketopiperazines from Acrostalagmus luteoalbus, a Marine Algal Isolate of Endophytic Fungus".CHINESE JOURNAL OF CHEMISTRY (2021):7.
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