IOCAS-IR  > 实验海洋生物学重点实验室
Edwardsiella tarda outer membrane protein 1 is a virulence factor and a protective immunogen
Jin, Cheng-dong1,2,3; Li, Mo-fei1,2
2021-06-30
发表期刊AQUACULTURE
ISSN0044-8486
卷号539页码:9
通讯作者Li, Mo-fei(limofei@qdio.ac.cn)
摘要The bacterial outer membrane proteins are important components of bacterial cell. Edwardsiella tarda is a vital bacterial pathogen to a wide range of aquaculture animals. In this study, we examined the function of an outer membrane protein of E. tarda (named Omp1Et). Omp1Et was found to localize on the surface of E. tarda, and recombinant Omp1Et (rOmp1Et) was able to interact with flounder peripheral blood leukocytes. Compared to the wild type, the omp1Et knockout TX01?omp1 was significantly reduced in motility, biofilm formation, attachment and invasion into host cells, dissemination in host tissues, and inducing host mortality. Furthermore, TX01?omp1 was significantly impaired in the ability to survive under low pH and oxidizing conditions. When introduced into flounder as a subunit vaccine, rOmp1Et induced strong immune protection against E. tarda challenge. Taken together, these results indicate that Omp1Et is a surface-located virulence factor of E. tarda and rOmp1Et can induce effective immune-protection as a submit vaccine.
关键词Edwardsiella tarda Outer membrane protein Virulence Vaccine
DOI10.1016/j.aquaculture.2021.736596
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[31972831] ; National Key Research and Development Program of China[2018YFD0900501] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2017249] ; Huiquan Young Scholar Program of Institute of Oceanology, CAS ; Taishan Scholar Program of Shandong Province
WOS研究方向Fisheries ; Marine & Freshwater Biology
WOS类目Fisheries ; Marine & Freshwater Biology
WOS记录号WOS:000644225600001
出版者ELSEVIER
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/170869
专题实验海洋生物学重点实验室
通讯作者Li, Mo-fei
作者单位1.Chinese Acad Sci, CAS Ctr Ocean Megasci, Inst Oceanol, CAS Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, 1 Wenhai Rd, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
第一作者单位中国科学院海洋大科学研究中心
通讯作者单位中国科学院海洋大科学研究中心
推荐引用方式
GB/T 7714
Jin, Cheng-dong,Li, Mo-fei. Edwardsiella tarda outer membrane protein 1 is a virulence factor and a protective immunogen[J]. AQUACULTURE,2021,539:9.
APA Jin, Cheng-dong,&Li, Mo-fei.(2021).Edwardsiella tarda outer membrane protein 1 is a virulence factor and a protective immunogen.AQUACULTURE,539,9.
MLA Jin, Cheng-dong,et al."Edwardsiella tarda outer membrane protein 1 is a virulence factor and a protective immunogen".AQUACULTURE 539(2021):9.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
1-s2.0-S004484862100(3824KB)期刊论文出版稿限制开放CC BY-NC-SA浏览
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jin, Cheng-dong]的文章
[Li, Mo-fei]的文章
百度学术
百度学术中相似的文章
[Jin, Cheng-dong]的文章
[Li, Mo-fei]的文章
必应学术
必应学术中相似的文章
[Jin, Cheng-dong]的文章
[Li, Mo-fei]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 1-s2.0-S0044848621002581-main.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。