IOCAS-IR
Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury
Wu, Jianzhang1; Xi, Yiyuan1; Li, Ge1; Zheng, Yuantie1; Wang, Zhongle1; Wang, Jingsong1; Fang, Chengyan1; Sun, Zhongmin2; Hu, Linya1; Jiang, Wei3; Dai, Lishang1; Dong, Jianyong1; Qiu, Peihong1; Zhao, Min1; Yan, Pengcheng1
2021-04-23
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume84Issue:4Pages:1306-1315
Corresponding AuthorZhao, Min(zhaomin@wmu.edu.cn) ; Yan, Pengcheng(yanpc@wmu.edu.cn)
AbstractFive new diterpenes, including four new hydroazulenes, (8R,11R)-8, 11- diacetoxypachydictyol A (1), (8R*,11R*) -6-O-acety1-8- acetoxy-11-hydroxypachydictyol A (2), (8R*,11S*)-8-acetoxy-11-hydroxypachydictyol A (3), and (8R*,11S*)-6-O-acety1-8,11-dihydroxypachydictyol A (4), and a secohydroazulene derivative, named 7Z-7,8-seco-7,11-didehydro-8-acetoxypachydictyol A (5), were isolated from a South China Sea collection of a Dictyota sp. nov. brown alga, together with five known analogues (6-10). Structure elucidation was achieved by extensive spectroscopic analysis and comparison with reported data. All compounds showed potent antioxidant effects against H2O2-induced oxidative damage in neuron-like PC12 cells at a low concentration of 2 mu M. The antioxidant property of dictyol C (9) was associated with activation of the Nrf2/ARE signaling pathway; it also showed neuroprotective effects against cerebral ischemia-reperfusion injury (CIRI) in a rat model of transient middle cerebral artery occlusion. As such, hydroazulene diterpenes could serve as lead structures for the development of novel neuroprotective agents against CIRI.
DOI10.1021/acs.jnatprod.1c00027
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of Zhejiang Province, China[LQ19H300003] ; National Natural Science Foundation of China[82073761] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences[201707]
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000644478400038
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/170860
Collection中国科学院海洋研究所
Corresponding AuthorZhao, Min; Yan, Pengcheng
Affiliation1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
3.Yangzhou Univ, Sch Environm Sci & Engn, Yangzhou 225127, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Wu, Jianzhang,Xi, Yiyuan,Li, Ge,et al. Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(4):1306-1315.
APA Wu, Jianzhang.,Xi, Yiyuan.,Li, Ge.,Zheng, Yuantie.,Wang, Zhongle.,...&Yan, Pengcheng.(2021).Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury.JOURNAL OF NATURAL PRODUCTS,84(4),1306-1315.
MLA Wu, Jianzhang,et al."Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury".JOURNAL OF NATURAL PRODUCTS 84.4(2021):1306-1315.
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