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| Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury | |
Wu, Jianzhang1; Xi, Yiyuan1; Li, Ge1; Zheng, Yuantie1; Wang, Zhongle1; Wang, Jingsong1; Fang, Chengyan1; Sun, Zhongmin2; Hu, Linya1; Jiang, Wei3 ; Dai, Lishang1; Dong, Jianyong1; Qiu, Peihong1; Zhao, Min1; Yan, Pengcheng1
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| 2021-04-23 | |
| Source Publication | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| Volume | 84Issue:4Pages:1306-1315 |
| Corresponding Author | Zhao, Min(zhaomin@wmu.edu.cn) ; Yan, Pengcheng(yanpc@wmu.edu.cn) |
| Abstract | Five new diterpenes, including four new hydroazulenes, (8R,11R)-8, 11- diacetoxypachydictyol A (1), (8R*,11R*) -6-O-acety1-8- acetoxy-11-hydroxypachydictyol A (2), (8R*,11S*)-8-acetoxy-11-hydroxypachydictyol A (3), and (8R*,11S*)-6-O-acety1-8,11-dihydroxypachydictyol A (4), and a secohydroazulene derivative, named 7Z-7,8-seco-7,11-didehydro-8-acetoxypachydictyol A (5), were isolated from a South China Sea collection of a Dictyota sp. nov. brown alga, together with five known analogues (6-10). Structure elucidation was achieved by extensive spectroscopic analysis and comparison with reported data. All compounds showed potent antioxidant effects against H2O2-induced oxidative damage in neuron-like PC12 cells at a low concentration of 2 mu M. The antioxidant property of dictyol C (9) was associated with activation of the Nrf2/ARE signaling pathway; it also showed neuroprotective effects against cerebral ischemia-reperfusion injury (CIRI) in a rat model of transient middle cerebral artery occlusion. As such, hydroazulene diterpenes could serve as lead structures for the development of novel neuroprotective agents against CIRI. |
| DOI | 10.1021/acs.jnatprod.1c00027 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Natural Science Foundation of Zhejiang Province, China[LQ19H300003] ; National Natural Science Foundation of China[82073761] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences[201707] |
| WOS Research Area | Plant Sciences ; Pharmacology & Pharmacy |
| WOS Subject | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS ID | WOS:000644478400038 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/170860 |
| Collection | 中国科学院海洋研究所 |
| Corresponding Author | Zhao, Min; Yan, Pengcheng |
| Affiliation | 1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Yangzhou Univ, Sch Environm Sci & Engn, Yangzhou 225127, Jiangsu, Peoples R China |
| Recommended Citation GB/T 7714 | Wu, Jianzhang,Xi, Yiyuan,Li, Ge,et al. Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(4):1306-1315. |
| APA | Wu, Jianzhang.,Xi, Yiyuan.,Li, Ge.,Zheng, Yuantie.,Wang, Zhongle.,...&Yan, Pengcheng.(2021).Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury.JOURNAL OF NATURAL PRODUCTS,84(4),1306-1315. |
| MLA | Wu, Jianzhang,et al."Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury".JOURNAL OF NATURAL PRODUCTS 84.4(2021):1306-1315. |
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| File Name/Size | DocType | Version | Access | License | ||
| acs.jnatprod.1c00027（3879KB） | 期刊论文 | 出版稿 | 延迟开放 | CC BY-NC-SA | View 2023-7-1后可获取 | |
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