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Identification of Growth-Associated Genes by Genome-Wide Association Study and Their Potential Application in the Breeding of Pacific White Shrimp (Litopenaeus vannamei)
Lyu, Ding1,2,3; Yu, Yang1,2,3; Wang, Quanchao1,3,4; Luo, Zheng1,3,5; Zhang, Qian1,3,5; Zhang, Xiaojun1,2,3; Xiang, Jianhai1,3; Li, Fuhua1,2,3,6
2021-04-07
Source PublicationFRONTIERS IN GENETICS
Volume12Pages:9
Corresponding AuthorLi, Fuhua(fhli@qdio.ac.cn)
AbstractThe Pacific white shrimp (Litopenaeus vannamei) is the most widely cultured shrimp in the world. A great attention has been paid to improve its body weight (BW) at harvest through genetic selection for decades. Genome-wide association study (GWAS) is a tool to dissect the genetic basis of the traits. In this study, a GWAS approach was conducted to find genes related to BW through genotyping 94,113 single nucleotide polymorphisms (SNPs) in 200 individuals from a breeding population. Four BW-related SNPs located in LG19 and LG39 were identified. Through further candidate gene association analysis, the SNPs in two candidate genes, deoxycytidylate deaminase and non-receptor protein tyrosine kinase, were found to be related with the body weight of the shrimp. Marker-assisted best linear unbiased prediction (MA-BLUP) based on the SNPs in these two genes was used to estimate the breeding values, and the result showed that the highest prediction accuracy of MA-BLUP was increased by 9.4% than traditional BLUP. These results will provide useful information for the marker-assisted breeding in L. vannamei.
KeywordGWAS growth trait marker assisted BLUP genetic breeding Litopenaeus vannamei
DOI10.3389/fgene.2021.611570
Indexed BySCI
Language英语
Funding ProjectStrategic Priority Research Program of the Chinese Academy of Sciences[XDA24030105] ; National Key R&D Program of China[2018YFD0901301] ; Agricultural Variety Improvement Project of Shandong Province[2019LZGC014] ; China Agriculture Research System-48[CARS-48]
WOS Research AreaGenetics & Heredity
WOS SubjectGenetics & Heredity
WOS IDWOS:000641715100001
PublisherFRONTIERS MEDIA SA
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/170631
Collection实验海洋生物学重点实验室
Corresponding AuthorLi, Fuhua
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China
5.Univ Chinese Acad Sci, Beijing, Peoples R China
6.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Lyu, Ding,Yu, Yang,Wang, Quanchao,et al. Identification of Growth-Associated Genes by Genome-Wide Association Study and Their Potential Application in the Breeding of Pacific White Shrimp (Litopenaeus vannamei)[J]. FRONTIERS IN GENETICS,2021,12:9.
APA Lyu, Ding.,Yu, Yang.,Wang, Quanchao.,Luo, Zheng.,Zhang, Qian.,...&Li, Fuhua.(2021).Identification of Growth-Associated Genes by Genome-Wide Association Study and Their Potential Application in the Breeding of Pacific White Shrimp (Litopenaeus vannamei).FRONTIERS IN GENETICS,12,9.
MLA Lyu, Ding,et al."Identification of Growth-Associated Genes by Genome-Wide Association Study and Their Potential Application in the Breeding of Pacific White Shrimp (Litopenaeus vannamei)".FRONTIERS IN GENETICS 12(2021):9.
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