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The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review
Zhang, Jiajia1,2,4; Wu, Ning1,2; Shi, Dayong1,2,3,4
2021
发表期刊MINI-REVIEWS IN MEDICINAL CHEMISTRY
ISSN1389-5575
卷号21期号:7页码:803-815
通讯作者Wu, Ning(wuning@qdio.ac.cn) ; Shi, Dayong(shidayong@sdu.edu.cn)
摘要Background: The mammalian target of rapamycin (mTOR), protein tyrosine phosphatase 1b (PTP1B) and dipeptidase 4 (DPP4) signaling pathways regulate eukaryotic cell proliferation and metabolism. Previous researches described different transduction mechanisms in the progression of cancer and diabetes. Methodology: We reviewed recent advances in the signal transduction pathways of mTOR, PTP1B and DPP4 regulation and determined the crosstalk and common pathway in diabetes and cancer. Results: We showed that according to numerous past studies, the proteins participate in the signaling networks for both diseases. Conclusion: There are common pathways and specific proteins involved in diabetes and cancer. This article demonstrates and explains the potential mechanisms of association and future prospects for targeting these proteins in pharmacological studies.
关键词Signaling pathway mammalian target of rapamycin protein tyrosine phosphatase 1b dipeptidase 4 cancer diabetes pharmacology target compounds
DOI10.2174/1389557520666201113110406
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[81803375] ; National Natural Science Foundation of China[81773586] ; National Natural Science Foundation of China[81903354] ; National Natural Science Foundation of China[81872906]
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000631285400002
出版者BENTHAM SCIENCE PUBL LTD
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/170279
专题中国科学院海洋大科学研究中心
通讯作者Wu, Ning; Shi, Dayong
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China
2.Lab Marine Drugs & Bioprod Qingdao Natl Lab Marin, Qingdao, Shandong, Peoples R China
3.Shandong Univ, State Key Lab Microbial Technol, Jinan, Shandong, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
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Zhang, Jiajia,Wu, Ning,Shi, Dayong. The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2021,21(7):803-815.
APA Zhang, Jiajia,Wu, Ning,&Shi, Dayong.(2021).The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review.MINI-REVIEWS IN MEDICINAL CHEMISTRY,21(7),803-815.
MLA Zhang, Jiajia,et al."The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review".MINI-REVIEWS IN MEDICINAL CHEMISTRY 21.7(2021):803-815.
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