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Structural characterization and immunostimulatory activity in vitro of a glycogen from sea urchin-Strongylocentyotus internedius
Wang, Qing-Chi1,2,3,4; Wei, Maosheng1,2,3,4; Yue, Yang1,2,3,4; Wu, Ning1,2,3,4; Wang, Jing1,2,3,4; Zhang, Quanbin1,2,3,4
2021-04-15
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume258Pages:14
Corresponding AuthorZhang, Quanbin(qbzhang@qdio.ac.cn)
AbstractSea urchin possesses both high nutritional and medicinal value. It contains diverse biological active polysaccharides. But there are few studies on its glycogen. In the current study, a glucan (MSGA) was separated from Strongylocentyotus internedius and purified by ion exchange and gel filtration column. Chemical analysis revealed that MSGA with 2.65 x 10(7) Da is made up entirely of glucose. The analysis of methylation, NMR and mass spectrum demonstrated that MSGA is a highly branched glycogen with alpha-(1 -> 4) linked gluconic backbone and branched at C-6 (one branch per five residues). In addition, MSGA showed good in vitro immunostimulatory activity via NF-kappa B and MAPKs pathways. It is considered that high degree of branching is necessary for its activity. However, the relationship between structure and immunostimulatory activity of natural glycogens is difficult to elucidate because the difference in their structural properties. Therefore, much more research is needed in this area.
KeywordStrongylocentyotus internedius Glycogen Structural characterization Immunostimulatory activity RAW264.7 macrophage
DOI10.1016/j.carbpol.2021.117701
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFD0901104] ; National Key R&D Program of China[2019YFD0900705]
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000620151600005
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/170133
Collection实验海洋生物学重点实验室
Corresponding AuthorZhang, Quanbin
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Dept Earth Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Corresponding Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Qing-Chi,Wei, Maosheng,Yue, Yang,et al. Structural characterization and immunostimulatory activity in vitro of a glycogen from sea urchin-Strongylocentyotus internedius[J]. CARBOHYDRATE POLYMERS,2021,258:14.
APA Wang, Qing-Chi,Wei, Maosheng,Yue, Yang,Wu, Ning,Wang, Jing,&Zhang, Quanbin.(2021).Structural characterization and immunostimulatory activity in vitro of a glycogen from sea urchin-Strongylocentyotus internedius.CARBOHYDRATE POLYMERS,258,14.
MLA Wang, Qing-Chi,et al."Structural characterization and immunostimulatory activity in vitro of a glycogen from sea urchin-Strongylocentyotus internedius".CARBOHYDRATE POLYMERS 258(2021):14.
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