Characterization and Expression Analysis of Insulin Growth Factor Binding Proteins (IGFBPs) in Pacific White Shrimp Litopenaeus vannamei

doi:10.3390/ijms22031056

IOCAS-IR > 实验海洋生物学重点实验室

	Characterization and Expression Analysis of Insulin Growth Factor Binding Proteins (IGFBPs) in Pacific White Shrimp Litopenaeus vannamei
	Pang, Ying 1,2,3; Zhang, Xiaojun 1,2,4; Yuan, Jianbo 1,2,4; Zhang, Xiaoxi1,2,4 ; Xiang, Jianhai1,2,4 ; Li, Fuhua 1,2,4
	2021-02-01
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号	22 期号:3 页码:14
通讯作者	Zhang, Xiaojun(xjzhang@qdio.ac.cn)
摘要	The insulin signaling (IIS) pathway plays an important role in the metabolism, growth, development, reproduction, and longevity of an organism. As a key member of the IIS pathway, insulin-like growth factor binding proteins (IGFBPs) are widely distributed a family in invertebrates and vertebrates that are critical in various aspects of physiology. As an important mariculture species, the growth of Pacific white shrimp, Litopenaeus vannamei, is one of the most concerning characteristics in this area of study. In this study, we identified three IGFBP genes in the genome of L. vannamei and analyzed their gene structures, phylogenetics, and expression profiles. LvIGFBP1 was found to contain three domains (the insulin growth factor binding (IB) domain, the Kazal-type serine proteinase inhibitor (Kazal) domain, and the immunoglobulin C-2 (IGc2) domain), while LvIGFBP2 and LvIGFBP3 only contained a single IB domain. LvIGFBP1 exhibited high expression in most tissues and different developmental stages, while LvIGFBP2 and LvIGFBP3 were only slightly expressed in hemocytes. The RNA interference of LvIGFBP1 resulted in a significantly smaller increment of body weight than that of control groups. These results will improve our understanding of the conservative structure and function of IGFBPs and show potential applications for the growth of shrimp.
关键词	insulin growth factor binding proteins Litopenaeus vannamei gene structures gene expression growth
DOI	10.3390/ijms22031056
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2018YFD0900103] ; National Key R&D Program of China[2018YFD0900404] ; National Natural Sciences Foundation of China[31972782] ; National Natural Sciences Foundation of China[31672632] ; National Natural Sciences Foundation of China[41876167] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24030105]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000615315000001
出版者	MDPI
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/170088
专题	实验海洋生物学重点实验室
通讯作者	Zhang, Xiaojun
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
第一作者单位	实验海洋生物学重点实验室
通讯作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Pang, Ying,Zhang, Xiaojun,Yuan, Jianbo,et al. Characterization and Expression Analysis of Insulin Growth Factor Binding Proteins (IGFBPs) in Pacific White Shrimp Litopenaeus vannamei[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2021,22(3):14.
APA	Pang, Ying,Zhang, Xiaojun,Yuan, Jianbo,Zhang, Xiaoxi,Xiang, Jianhai,&Li, Fuhua.(2021).Characterization and Expression Analysis of Insulin Growth Factor Binding Proteins (IGFBPs) in Pacific White Shrimp Litopenaeus vannamei.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,22(3),14.
MLA	Pang, Ying,et al."Characterization and Expression Analysis of Insulin Growth Factor Binding Proteins (IGFBPs) in Pacific White Shrimp Litopenaeus vannamei".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22.3(2021):14.

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