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The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
Song, Hao1,2,3,4; Guo, Ximing5; Sun, Lina1,2,3,4,6; Wang, Qianghui8; Han, Fengming8; Wang, Haiyan1,2,3,6; Wray, Gregory A.9; Davidson, Phillip9; Wang, Qing6,7; Hu, Zhi1,2,6; Zhou, Cong1,2,6; Yu, Zhenglin1,2,3,4; Yang, Meijie1,2,6; Feng, Jie1,2,3,4; Shi, Pu1,2,6; Zhou, Yi1,2,3,4,6; Zhang, Libin1,2,3,4,6; Zhang, Tao1,2,3,4,6
2021-01-25
Source PublicationBMC BIOLOGY
Volume19Issue:1Pages:20
Corresponding AuthorZhang, Tao(tzhang@qdio.ac.cn)
AbstractBackground Inhibitors of apoptosis (IAPs) are critical regulators of programmed cell death that are essential for development, oncogenesis, and immune and stress responses. However, available knowledge regarding IAP is largely biased toward humans and model species, while the distribution, function, and evolutionary novelties of this gene family remain poorly understood in many taxa, including Mollusca, the second most speciose phylum of Metazoa. Results Here, we present a chromosome-level genome assembly of an economically significant bivalve, the hard clam Mercenaria mercenaria, which reveals an unexpected and dramatic expansion of the IAP gene family to 159 members, the largest IAP gene repertoire observed in any metazoan. Comparative genome analysis reveals that this massive expansion is characteristic of bivalves more generally. Reconstruction of the evolutionary history of molluscan IAP genes indicates that most originated in early metazoans and greatly expanded in Bivalvia through both lineage-specific tandem duplication and retroposition, with 37.1% of hard clam IAPs located on a single chromosome. The expanded IAPs have been subjected to frequent domain shuffling, which has in turn shaped their architectural diversity. Further, we observed that extant IAPs exhibit dynamic and orchestrated expression patterns among tissues and in response to different environmental stressors. Conclusions Our results suggest that sophisticated regulation of apoptosis enabled by the massive expansion and diversification of IAPs has been crucial for the evolutionary success of hard clam and other molluscan lineages, allowing them to cope with local environmental stresses. This study broadens our understanding of IAP proteins and expression diversity and provides novel resources for studying molluscan biology and IAP function and evolution.
KeywordIAP gene family Molecular evolution Mollusca Gene duplication Divergence
DOI10.1186/s12915-020-00943-9
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2019YFD0900800] ; earmarked fund for the Modern Agro-industry Technology Research System[CARS-49] ; Major Applied Technology Innovation Project in Agriculture of Shandong Province[SF1405303301] ; Supporting Program of Science and Technology Service Network Initiative in Fujian Province[2017 T3014] ; Industry Leading Talents Project of Taishan Scholars ; Double Hundred Blue Industry Leader Team of Yantai
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS IDWOS:000613072400002
PublisherBMC
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/170070
Collection海洋生态与环境科学重点实验室
Corresponding AuthorZhang, Tao
Affiliation1.Chinese Acad Sci, CAS Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China
5.Rutgers State Univ, Dept Marine & Coastal Sci, Haskin Shellfish Res Lab, Port Norris, NJ USA
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
7.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai 264003, Peoples R China
8.Novogene Bioinformat Inst, Beijing 100029, Peoples R China
9.Duke Univ, 130 Sci Dr, Durham, NC 27708 USA
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Song, Hao,Guo, Ximing,Sun, Lina,et al. The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia[J]. BMC BIOLOGY,2021,19(1):20.
APA Song, Hao.,Guo, Ximing.,Sun, Lina.,Wang, Qianghui.,Han, Fengming.,...&Zhang, Tao.(2021).The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia.BMC BIOLOGY,19(1),20.
MLA Song, Hao,et al."The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia".BMC BIOLOGY 19.1(2021):20.
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