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Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms
Wang, Ya-Nan1,2,3; Meng, Ling-Hong1,2; Wang, Bin-Gui1,2,4
2020-12-01
Source PublicationMARINE DRUGS
Volume18Issue:12Pages:26
Corresponding AuthorMeng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractDeep sea has an extreme environment which leads to biodiversity of microorganisms and their unique physical and biochemical mechanisms. Deep-sea derived microorganisms are more likely to produce novel bioactive substances with special mechanism of action for drug discovery. This article reviews secondary metabolites with biological activities such as anti-tumor, anti-bacterial, anti-viral, and anti-inflammatory isolated from deep-sea fungi and bacteria during 2018-2020. Effective methods for screening and obtaining natural active compounds from deep-sea microorganisms are also summarized, including optimizing the culture conditions, using genome mining technology, biosynthesis and so on. The comprehensive application of these methods makes broader prospects for the development and application of deep sea microbial bioactive substances.
Keyworddeep-sea fungi deep-sea actinomycetes secondary metabolites bioactivity
DOI10.3390/md18120614
Indexed BySCI
Language英语
Funding ProjectStrategic Priority Research Program of the Chinese Academy of Sciences[XDA22050401] ; Natural Science Foundation of China[41976090] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017250] ; Taishan Scholar Project from Shandong Province
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000602115300001
PublisherMDPI
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/169570
Collection实验海洋生物学重点实验室
Corresponding AuthorMeng, Ling-Hong; Wang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Coll Earth Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Ya-Nan,Meng, Ling-Hong,Wang, Bin-Gui. Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms[J]. MARINE DRUGS,2020,18(12):26.
APA Wang, Ya-Nan,Meng, Ling-Hong,&Wang, Bin-Gui.(2020).Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms.MARINE DRUGS,18(12),26.
MLA Wang, Ya-Nan,et al."Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms".MARINE DRUGS 18.12(2020):26.
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