Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms

doi:10.3390/md18120614

IOCAS-IR > 实验海洋生物学重点实验室

	Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms
	Wang, Ya-Nan 1,2,3; Meng, Ling-Hong1,2 ; Wang, Bin-Gui1,2,4
	2020-12-01
发表期刊	MARINE DRUGS
卷号	18 期号:12 页码:26
通讯作者	Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
摘要	Deep sea has an extreme environment which leads to biodiversity of microorganisms and their unique physical and biochemical mechanisms. Deep-sea derived microorganisms are more likely to produce novel bioactive substances with special mechanism of action for drug discovery. This article reviews secondary metabolites with biological activities such as anti-tumor, anti-bacterial, anti-viral, and anti-inflammatory isolated from deep-sea fungi and bacteria during 2018-2020. Effective methods for screening and obtaining natural active compounds from deep-sea microorganisms are also summarized, including optimizing the culture conditions, using genome mining technology, biosynthesis and so on. The comprehensive application of these methods makes broader prospects for the development and application of deep sea microbial bioactive substances.
关键词	deep-sea fungi deep-sea actinomycetes secondary metabolites bioactivity
DOI	10.3390/md18120614
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050401] ; Natural Science Foundation of China[41976090] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017250] ; Taishan Scholar Project from Shandong Province
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000602115300001
出版者	MDPI
引用统计	被引频次：38[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/169570
专题	实验海洋生物学重点实验室
通讯作者	Meng, Ling-Hong; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Wang, Ya-Nan,Meng, Ling-Hong,Wang, Bin-Gui. Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms[J]. MARINE DRUGS,2020,18(12):26.
APA	Wang, Ya-Nan,Meng, Ling-Hong,&Wang, Bin-Gui.(2020).Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms.MARINE DRUGS,18(12),26.
MLA	Wang, Ya-Nan,et al."Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms".MARINE DRUGS 18.12(2020):26.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
marinedrugs-18-00614（5301KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览