Short-term exposure to norfloxacin induces oxidative stress, neurotoxicity and microbiota alteration in juvenile large yellow croaker Pseudosciaena crocea

doi:10.1016/j.envpol.2020.115397

	Short-term exposure to norfloxacin induces oxidative stress, neurotoxicity and microbiota alteration in juvenile large yellow croaker Pseudosciaena crocea
	Wang, Xinghuo 1,2,3; Hu, Menghong 2,3; Gu, Huaxin 2,3; Zhang, Libin 4,5; Shang, Yueyong 2,3; Wang, Ting 2,3; Wang, Tingyue 2,3; Zeng, Jiangning 1,4; Ma, Lukuo 1; Huang, Wei 1,4; Wang, Youji 1,2,3,4
	2020-12-01
发表期刊	ENVIRONMENTAL POLLUTION
ISSN	0269-7491
卷号	267 页码:9
通讯作者	Huang, Wei(willhuang@sio.org.cn)
摘要	In recent years, antibiotics have been widely detected in coastal waters of China, which raising concerns for coastal biodiversity and aquaculture. This study evaluated the effects of short-term exposure of norfloxacin (NOR) on oxidative stress and intestinal health of the large yellow croaker Pseudosciaena crocea. Juvenile fish were exposed to four concentrations of NOR (0.1, 10, 100 and 1000 mu g/L) for 14 days. The results showed that NOR inhibited growth and threatened the survival of juveniles. According to the changes of intestinal microbiota, we found that NOR led to a significant decrease in intestinal microbiota diversity, with the decreased relative abundance of Proteobacteria, but the increased Tenericutes. From the perspective of microbial function, NOR inhibited metabolism, cellular defence mechanism and information transduction process. In terms of biochemical indicators, NOR caused an increase in malondialdehyde (MDA) level and inhibited superoxide dismutase (SOD) and acetyl cholinesterase (AChE) activities. Catalase (CAT) activity was activated at low concentration but significantly inhibited at high concentration of NOR. Moreover, there was a high correlation between change in biochemical indicators and change in the microbial community. Overall, environmentally relevant concentrations (0.1 mu g/L) and high concentrations (10, 100 and 1000 mu g/L) of NOR have negative effects on the defence function and intestinal health of large yellow croaker juveniles. (c) 2020 Elsevier Ltd. All rights reserved.
关键词	AChE Fish Intestinal microbiota Norfloxacin Oxidative stress
DOI	10.1016/j.envpol.2020.115397
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2019YFD0901101] ; National Key R&D Program of China[2018YFD0900901] ; State Key Laboratory of Satellite Ocean Environment Dynamics[SOEDZZ 1902] ; ChinaASEAN Maritime Cooperation Fund Project ; Joint Advanced Marine and Ecological Studies in the Bay of Bengal and the eastern equatorial Indian Ocean (JAMES) ; Key Projects of Philosophy and Social Sciences Research,Ministry of Education[18JZD059] ; ChinaAPEC Cooperation Fund[2029901]
WOS研究方向	Environmental Sciences & Ecology
WOS类目	Environmental Sciences
WOS记录号	WOS:000593966000012
出版者	ELSEVIER SCI LTD
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/169472
专题	海洋生态与环境科学重点实验室
通讯作者	Huang, Wei
作者单位	1.Minist Nat Resources, Inst Oceanog 2, Key Lab Marine Ecosyst Dynam, Hangzhou 310012, Peoples R China 2.Shanghai Ocean Univ, Minist Sci & Technol, Int Res Ctr Marine Biosci, Shanghai 201306, Peoples R China 3.Shanghai Ocean Univ, Minist Educ, Key Lab Explorat & Utilizat Aquat Genet Resources, Shanghai 201306, Peoples R China 4.Minist Nat Resources, Inst Oceanog 2, State Key Lab Satellite Ocean Environm Dynam, Hangzhou 310012, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xinghuo,Hu, Menghong,Gu, Huaxin,et al. Short-term exposure to norfloxacin induces oxidative stress, neurotoxicity and microbiota alteration in juvenile large yellow croaker Pseudosciaena crocea[J]. ENVIRONMENTAL POLLUTION,2020,267:9.
APA	Wang, Xinghuo.,Hu, Menghong.,Gu, Huaxin.,Zhang, Libin.,Shang, Yueyong.,...&Wang, Youji.(2020).Short-term exposure to norfloxacin induces oxidative stress, neurotoxicity and microbiota alteration in juvenile large yellow croaker Pseudosciaena crocea.ENVIRONMENTAL POLLUTION,267,9.
MLA	Wang, Xinghuo,et al."Short-term exposure to norfloxacin induces oxidative stress, neurotoxicity and microbiota alteration in juvenile large yellow croaker Pseudosciaena crocea".ENVIRONMENTAL POLLUTION 267(2020):9.

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