Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus

doi:10.1016/j.ygeno.2020.09.017

	Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus
	Zhang, Hongxia 1,2,3,4; Wang, Qing 3,5; Zhao, Jianmin 3,5; Liu, Shilin 1,2,3,4; Zhang, Libin 1,2,3,4,8; Zhao, Ye6 ; Yang, Hongsheng1,2,3,4,7 ; Sun, Lina 1,2,3,4
	2020-11-01
发表期刊	GENOMICS
ISSN	0888-7543
卷号	112 期号:6 页码:5012-5020
通讯作者	Sun, Lina(sunlina@qdio.ac.cn)
摘要	The intestinal microbiota may play important roles in regenerating intestine of the sea cucumber Apostichopus japonicus, the underlying mechanism remains unclear. In the present study, a germ-free sea cucumber model was developed, and the intestinal microbial differentiation of faster and slower regenerating A. japonicus individuals during intestine regeneration was analyzed. The results revealed that depletion of the intestinal microbiota resulted in elevated abundance of the potential key players Flavobacteriaceae and Rhodobacteraceae during intestine regeneration and thus promoted the intestine regeneration rate of A. japonicus. Metagenomic analysis revealed that the increased abundance of Flavobacteriaceae elevated the enrichment of genes associated with carbohydrate utilization, whereas the abundant Rhodobacteraceae-enriched genes were associated with polyhydroxybutyrate production. We identified microbiota abundance as a key driver of microbial community alterations, especially beneficial microbiota members, in the developing intestine of A. japonicus. This study provides new insights into the mechanism of host-microbiota interactions related to organ regeneration.
关键词	Apostichopus japonicus Intestine regeneration Intestinal microbiota Quantitative microbiome Regeneration rate
DOI	10.1016/j.ygeno.2020.09.017
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[41776162] ; China Postdoctoral Science Foundation[2018M642712] ; Youth Talent Support Program of the Laboratory for Marine Ecology and Environmental Science ; Pilot National Laboratory for Marine Science and Technology (Qingdao)[LMEES-YTSP-2018-01-09] ; Taishan Scholars Program (Distinguished Taishan Scholars), TwoHundred Talents Plan of Yantai[Y839081021] ; Youth Innovation Promotion Association CAS[2016196] ; Youth Innovation Promotion Association CAS[2019209] ; Chinese Academy of Sciences[KFJ-STS-ZDTP-023] ; Chinese Academy of Sciences[133137KYSB20180069]
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:000600731500010
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/169439
专题	海洋生态与环境科学重点实验室
通讯作者	Sun, Lina
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, CAS Res & Dev Ctr Efficient Utilizat Coastal Bior, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 6.Yantai Univ, Ocean Sch, Yantai 264005, Peoples R China 7.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China 8.Minist Nat Resources, Inst Oceanog 2, State Key Lab Satellite Ocean Environm Dynam, Hangzhou 310012, Peoples R China
第一作者单位	海洋生态与环境科学重点实验室; 中国科学院海洋研究所
通讯作者单位	海洋生态与环境科学重点实验室; 中国科学院海洋研究所
推荐引用方式 GB/T 7714	Zhang, Hongxia,Wang, Qing,Zhao, Jianmin,et al. Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus[J]. GENOMICS,2020,112(6):5012-5020.
APA	Zhang, Hongxia.,Wang, Qing.,Zhao, Jianmin.,Liu, Shilin.,Zhang, Libin.,...&Sun, Lina.(2020).Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus.GENOMICS,112(6),5012-5020.
MLA	Zhang, Hongxia,et al."Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus".GENOMICS 112.6(2020):5012-5020.

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