Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3

doi:10.1002/cbdv.202000566

IOCAS-IR > 实验海洋生物学重点实验室

	Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3
	Shi, Xiao-Shan1,2,3 ; Meng, Ling-Hong1,2 ; Li, Xin1,2 ; Wang, Dun-Jia 3; Zhou, Xing-Wang 3; Du, Feng-Yu 4; Wang, Bin-Gui1,2,5 ; Li, Xiao-Ming 1,2,5
	2020-11-03
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
页码	9
通讯作者	Li, Xiao-Ming(lixmqd@qdio.ac.cn)
摘要	The AcOEt extract of Artemisia argyi-derived fungus Trichoderma koningiopsis QA-3 showed potent inhibitory activity against pathogenic bacteria. Fractionation of the extract resulted in the isolation of three new polyketides (1-3) and two new terpenoids (4 and 5), together with three known metabolites (6-8). Their chemical structures were analyzed by NMR spectra, ECD, HR-ESI-MS or HR-EI-MS, optical rotation, and X-ray crystallographic data, as well as by comparison with literature reports. In the antibacterial assays, 3-hydroxyharziandione (4) showed potent activity against human pathogen Escherichia coli with an MIC value of 0.5 mu g/mL, while 6-(3-hydroxypent-1-en-1-yl)-2H-pyran-2-one exhibited strong activity against marine-derived aquatic pathogen Micrococcus luteus with an MIC value of 1.0 mu g/mL.
关键词	Trichoderma koningiopsis Artemisia argyi polyketides terpenoids antibacterial activity
DOI	10.1002/cbdv.202000566
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31870328] ; Taishan Scholar Program from Shandong Province, China[ts201511060]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000584000700001
出版者	WILEY-V C H VERLAG GMBH
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/168996
专题	实验海洋生物学重点实验室
通讯作者	Li, Xiao-Ming
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Hubei Normal Univ, Coll Chem & Chem Engn, Cihu Rd 11, Huangshi 435002, Hubei, Peoples R China 4.Qingdao Agr Univ, Coll Chem & Pharm, Changcheng Rd 700, Qingdao 266109, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Shi, Xiao-Shan,Meng, Ling-Hong,Li, Xin,et al. Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3[J]. CHEMISTRY & BIODIVERSITY,2020:9.
APA	Shi, Xiao-Shan.,Meng, Ling-Hong.,Li, Xin.,Wang, Dun-Jia.,Zhou, Xing-Wang.,...&Li, Xiao-Ming.(2020).Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3.CHEMISTRY & BIODIVERSITY,9.
MLA	Shi, Xiao-Shan,et al."Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3".CHEMISTRY & BIODIVERSITY (2020):9.

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