Visible light driven photoelectrochemical thrombin aptasensor based on uniform TiO2 nanotube arrays modified with CuOx and perylene-3,4,9,10-tetracarboxylic acid

doi:10.1016/j.electacta.2020.136774

	Visible light driven photoelectrochemical thrombin aptasensor based on uniform TiO2 nanotube arrays modified with CuOx and perylene-3,4,9,10-tetracarboxylic acid
	Zhang, Qiaoxia 1,2; Lyu, Haoyuan 1,2; Li, Ning 1,2; Liu, Qing1,2 ; Zhang, Xianxi 3; Zhang, Xiao 4; Wang, Xiutong 5; Qingyun, Liu 1,2
	2020-09-10
发表期刊	ELECTROCHIMICA ACTA
ISSN	0013-4686
卷号	354 页码:9
通讯作者	Wang, Xiutong() ; Qingyun, Liu(qyliu@sdust.edu.cn)
摘要	In this work, a sensitive signal-off photoelectrochemical (PEC) thrombin aptasensor with satisfying specificity is proposed, in which the evident initial photocurrent response is produced by the photoanode and the signal amplification strategy toward the target is based on the specific bio-affinity properties between thrombin and their aptamers. The photoanode was fabricated with uniform TiO2 nanotube arrays decorated with CuOx and perylene-3,4,9,10-tetracarboxylic acid (PTCA). After the decoration of CuOx and PTCA, both possessing a strong absorption in visible region, the photocurrent response is improved greatly. Pt nanoparticles were modified on the photoanode electrode to immobilize thrombin aptamers, which could obviously improve the conductivity of the photoanode electrode owing to the excellent conductivity of Pt nanoparticles. The non-conductive complex leads to dramatical decrease in the photocurrent value due to the steric hinder effect. Based on the joint action of evident photocurrent response of photoanode and significant signal amplification strategy, the aptasensor in this project offers a wide linear range from 0.0003 nM to 10 nM, with a detection limit (3S/N) of thrombin down to 55 fM. Moreover, the as-fabricated aptasensor exhibits acceptable selectivity and stability, providing a meaningful attempt for the detection of thrombin. (C) 2020 Elsevier Ltd. All rights reserved.
关键词	Thrombin Photoelectrochemical aptasensor TiO2/CuOx Perylene-3,4,9,10-tetracarboxylic acid
DOI	10.1016/j.electacta.2020.136774
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[21971152] ; Natural Science Foundation of Shandong Province[ZR2018MB002]
WOS研究方向	Electrochemistry
WOS类目	Electrochemistry
WOS记录号	WOS:000569145000012
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/168799
专题	海洋环境腐蚀与生物污损重点实验室
通讯作者	Wang, Xiutong; Qingyun, Liu
作者单位	1.Shandong Univ Sci & Technol, Coll Chem & Biol Engn, State Key Lab Min Disaster Prevent & Control Cofo, Qingdao 266590, Peoples R China 2.Shandong Univ Sci & Technol, Minist Sci & Technol, Qingdao 266590, Peoples R China 3.Liaocheng Univ, Shandong Prov Key Lab, Collaborat Innovat Ctr Chem Energy Storage & Nove, Sch Chem & Chem Engn, Liaocheng 252059, Shandong, Peoples R China 4.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China 5.Chinese Acad Sci, Key Lab Marine Environm Corros & Biofouling, Inst Oceanol, Qingdao 266071, Peoples R China
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Zhang, Qiaoxia,Lyu, Haoyuan,Li, Ning,et al. Visible light driven photoelectrochemical thrombin aptasensor based on uniform TiO2 nanotube arrays modified with CuOx and perylene-3,4,9,10-tetracarboxylic acid[J]. ELECTROCHIMICA ACTA,2020,354:9.
APA	Zhang, Qiaoxia.,Lyu, Haoyuan.,Li, Ning.,Liu, Qing.,Zhang, Xianxi.,...&Qingyun, Liu.(2020).Visible light driven photoelectrochemical thrombin aptasensor based on uniform TiO2 nanotube arrays modified with CuOx and perylene-3,4,9,10-tetracarboxylic acid.ELECTROCHIMICA ACTA,354,9.
MLA	Zhang, Qiaoxia,et al."Visible light driven photoelectrochemical thrombin aptasensor based on uniform TiO2 nanotube arrays modified with CuOx and perylene-3,4,9,10-tetracarboxylic acid".ELECTROCHIMICA ACTA 354(2020):9.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
1-s2.0-S001346862031（3000KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览