Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans

doi:10.1007/s00343-020-0088-4

	Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans
	Zhang Zhongshan 1; Wang Xiaomei 1; Pan Yongliang 1; Wang Zhanqi 1; Wen Zhengshun 2; Liu Feng 3; Mao Genxiang 4
	2020-05-03
发表期刊	JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN	2096-5508
页码	9
通讯作者	Zhang Zhongshan(01959@zjhu.edu.cn)
摘要	Pyropia haitanensispolysaccharide (LP) have been found for having many excellent functions such as anti-aging. UsingCaenorhabditis elegansmodels, we evaluated the anti-aging activity of LP by observing the lifespan, reproduction, pharyngeal pumping, stress response, quantitative fluorescence of polyglutamic acid, and nuclear localization of DAF-16 of worms. The results reveal that LP could extend the adult lifespan of wild-type and polyQ nematodes, indicating a connection of its anti-aging benefit with the toxicity-suppressing effect. The number of polyglutamic acid aggregates in high concentration groups decreased by 24.39% (P<0.05) to the control. The high-dose group strongly induced DAF-16 nuclear translocation over intermediate and cytosolic localizations compared with the control (P<0.001). Therefore, we believe that LP could extend the lifespan and reduce the protein aggregation inC. elegansthrough nuclear DAF-16 proportion GFP expression.
关键词	Pyropia haitanensis polysaccharide protein aggregation Caenorhabditis elegans
DOI	10.1007/s00343-020-0088-4
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31700307 41876165] ; Science and Technology Project of Huzhou[2017ZD2017] ; Key Research Program of Frontier Sciences, Chinese Academy of Sciences[QYZDB-SSW-DQC023]
WOS研究方向	Marine & Freshwater Biology ; Oceanography
WOS类目	Limnology ; Oceanography
WOS记录号	WOS:000565844000001
出版者	SCIENCE PRESS
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/168490
专题	海洋生态与环境科学重点实验室
通讯作者	Zhang Zhongshan
作者单位	1.Huzhou Univ, Huzhou Cent Hosp, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou 313000, Peoples R China 2.Zhejiang Ocean Univ, Zhejiang Prov Engn Technol Res Ctr Marine Biomed, Sch Food Sci & Pharmaceut, Zhoushan 316022, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 4.Zhejiang Hosp, Dept Geriatr, Zhejiang Prov Key Lab Geriatr, Hangzhou 310013, Peoples R China
推荐引用方式 GB/T 7714	Zhang Zhongshan,Wang Xiaomei,Pan Yongliang,et al. Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2020:9.
APA	Zhang Zhongshan.,Wang Xiaomei.,Pan Yongliang.,Wang Zhanqi.,Wen Zhengshun.,...&Mao Genxiang.(2020).Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,9.
MLA	Zhang Zhongshan,et al."Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans".JOURNAL OF OCEANOLOGY AND LIMNOLOGY (2020):9.

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