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| Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans | |
| Zhang Zhongshan1; Wang Xiaomei1; Pan Yongliang1; Wang Zhanqi1; Wen Zhengshun2; Liu Feng3; Mao Genxiang4 | |
| 2020-05-03 | |
| Source Publication | JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| ISSN | 2096-5508 |
| Pages | 9 |
| Corresponding Author | Zhang Zhongshan(01959@zjhu.edu.cn) |
| Abstract | Pyropia haitanensispolysaccharide (LP) have been found for having many excellent functions such as anti-aging. UsingCaenorhabditis elegansmodels, we evaluated the anti-aging activity of LP by observing the lifespan, reproduction, pharyngeal pumping, stress response, quantitative fluorescence of polyglutamic acid, and nuclear localization of DAF-16 of worms. The results reveal that LP could extend the adult lifespan of wild-type and polyQ nematodes, indicating a connection of its anti-aging benefit with the toxicity-suppressing effect. The number of polyglutamic acid aggregates in high concentration groups decreased by 24.39% (P<0.05) to the control. The high-dose group strongly induced DAF-16 nuclear translocation over intermediate and cytosolic localizations compared with the control (P<0.001). Therefore, we believe that LP could extend the lifespan and reduce the protein aggregation inC. elegansthrough nuclear DAF-16 proportion GFP expression. |
| Keyword | Pyropia haitanensis polysaccharide protein aggregation Caenorhabditis elegans |
| DOI | 10.1007/s00343-020-0088-4 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[31700307 41876165] ; Science and Technology Project of Huzhou[2017ZD2017] ; Key Research Program of Frontier Sciences, Chinese Academy of Sciences[QYZDB-SSW-DQC023] |
| WOS Research Area | Marine & Freshwater Biology ; Oceanography |
| WOS Subject | Limnology ; Oceanography |
| WOS ID | WOS:000565844000001 |
| Publisher | SCIENCE PRESS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/168490 |
| Collection | 海洋生态与环境科学重点实验室 |
| Corresponding Author | Zhang Zhongshan |
| Affiliation | 1.Huzhou Univ, Huzhou Cent Hosp, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou 313000, Peoples R China 2.Zhejiang Ocean Univ, Zhejiang Prov Engn Technol Res Ctr Marine Biomed, Sch Food Sci & Pharmaceut, Zhoushan 316022, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 4.Zhejiang Hosp, Dept Geriatr, Zhejiang Prov Key Lab Geriatr, Hangzhou 310013, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang Zhongshan,Wang Xiaomei,Pan Yongliang,et al. Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2020:9. |
| APA | Zhang Zhongshan.,Wang Xiaomei.,Pan Yongliang.,Wang Zhanqi.,Wen Zhengshun.,...&Mao Genxiang.(2020).Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,9. |
| MLA | Zhang Zhongshan,et al."Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans".JOURNAL OF OCEANOLOGY AND LIMNOLOGY (2020):9. |
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