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Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans
Zhang Zhongshan1; Wang Xiaomei1; Pan Yongliang1; Wang Zhanqi1; Wen Zhengshun2; Liu Feng3; Mao Genxiang4
2020-05-03
Source PublicationJOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN2096-5508
Pages9
Corresponding AuthorZhang Zhongshan(01959@zjhu.edu.cn)
AbstractPyropia haitanensispolysaccharide (LP) have been found for having many excellent functions such as anti-aging. UsingCaenorhabditis elegansmodels, we evaluated the anti-aging activity of LP by observing the lifespan, reproduction, pharyngeal pumping, stress response, quantitative fluorescence of polyglutamic acid, and nuclear localization of DAF-16 of worms. The results reveal that LP could extend the adult lifespan of wild-type and polyQ nematodes, indicating a connection of its anti-aging benefit with the toxicity-suppressing effect. The number of polyglutamic acid aggregates in high concentration groups decreased by 24.39% (P<0.05) to the control. The high-dose group strongly induced DAF-16 nuclear translocation over intermediate and cytosolic localizations compared with the control (P<0.001). Therefore, we believe that LP could extend the lifespan and reduce the protein aggregation inC. elegansthrough nuclear DAF-16 proportion GFP expression.
KeywordPyropia haitanensis polysaccharide protein aggregation Caenorhabditis elegans
DOI10.1007/s00343-020-0088-4
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31700307 41876165] ; Science and Technology Project of Huzhou[2017ZD2017] ; Key Research Program of Frontier Sciences, Chinese Academy of Sciences[QYZDB-SSW-DQC023]
WOS Research AreaMarine & Freshwater Biology ; Oceanography
WOS SubjectLimnology ; Oceanography
WOS IDWOS:000565844000001
PublisherSCIENCE PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/168490
Collection海洋生态与环境科学重点实验室
Corresponding AuthorZhang Zhongshan
Affiliation1.Huzhou Univ, Huzhou Cent Hosp, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou 313000, Peoples R China
2.Zhejiang Ocean Univ, Zhejiang Prov Engn Technol Res Ctr Marine Biomed, Sch Food Sci & Pharmaceut, Zhoushan 316022, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
4.Zhejiang Hosp, Dept Geriatr, Zhejiang Prov Key Lab Geriatr, Hangzhou 310013, Peoples R China
Recommended Citation
GB/T 7714
Zhang Zhongshan,Wang Xiaomei,Pan Yongliang,et al. Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2020:9.
APA Zhang Zhongshan.,Wang Xiaomei.,Pan Yongliang.,Wang Zhanqi.,Wen Zhengshun.,...&Mao Genxiang.(2020).Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,9.
MLA Zhang Zhongshan,et al."Pyropia haitanensispolysaccharide extends lifespan by inhibiting protein aggregation inCaenorhabditis elegans".JOURNAL OF OCEANOLOGY AND LIMNOLOGY (2020):9.
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