IOCAS-IR
The Risk of Gastrointestinal Hemorrhage in Low-Dose Aspirin Users with Diabetes Mellitus: Systematic Review and Meta-Analysis
Wang, Yashuo1; Wang, Wei2; Wang, Bin3; Wang, Yunyang4
2020-08-03
Source PublicationGASTROENTEROLOGY RESEARCH AND PRACTICE
ISSN1687-6121
Volume2020Pages:6
AbstractBackground. Our aim was to assess the risk of gastrointestinal (GI) hemorrhage associated with diabetes among patients taking low-dose aspirin (<= 325 mg/day). Methods. A systematic search was conducted for publication in English and Chinese using term equivalents for "GI hemorrhage", "aspirin", and "diabetes mellitus" up till April 2020. Electronic databases include PUBMED, EMBASE, Cochrane Library databases, Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, and VIP Database. Two independent authors searched databases and reviewed abstracts for comprehensive studies keeping adequate study quality. Data of weighted odds ratios were statistically evaluated and potential bias was checked. Results. Among 446 publications, eight case-control researches, including 1601 patients, were deemed for this meta-analysis. Patients with diabetes were associated with a higher risk of GI hemorrhage than patients without diabetes: the summary ORs were 3.10 (95% CI, 2.35-4.09). The heterogeneity of the reports was not significant (Chi(2)=3.39, P=0.85; I-2=0%). Conclusion. The meta-analysis showed that aspirin users with diabetes were more likely to have GI hemorrhage. Hence, when treating diabetics with aspirin, the increased risk of GI bleeding should be taken in consideration.
DOI10.1155/2020/9824615
Indexed BySCI
Language英语
WOS Research AreaGastroenterology & Hepatology
WOS SubjectGastroenterology & Hepatology
WOS IDWOS:000562863300001
PublisherHINDAWI LTD
Citation statistics
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/168325
Collection中国科学院海洋研究所
Corresponding AuthorWang, Yunyang
Affiliation1.Qingdao Univ, Coll Life Sci, Qingdao, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Beijing, Peoples R China
3.Qingdao Univ, Dept Med Microbiol, Med Coll, Qingdao, Shandong, Peoples R China
4.Qingdao Univ, Dept Endocrinol & Metab, Affiliated Hosp, Qingdao, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yashuo,Wang, Wei,Wang, Bin,et al. The Risk of Gastrointestinal Hemorrhage in Low-Dose Aspirin Users with Diabetes Mellitus: Systematic Review and Meta-Analysis[J]. GASTROENTEROLOGY RESEARCH AND PRACTICE,2020,2020:6.
APA Wang, Yashuo,Wang, Wei,Wang, Bin,&Wang, Yunyang.(2020).The Risk of Gastrointestinal Hemorrhage in Low-Dose Aspirin Users with Diabetes Mellitus: Systematic Review and Meta-Analysis.GASTROENTEROLOGY RESEARCH AND PRACTICE,2020,6.
MLA Wang, Yashuo,et al."The Risk of Gastrointestinal Hemorrhage in Low-Dose Aspirin Users with Diabetes Mellitus: Systematic Review and Meta-Analysis".GASTROENTEROLOGY RESEARCH AND PRACTICE 2020(2020):6.
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