Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5 | |
Li, Xin1,2 ; Li, Li1,3; Li, Xiao-Ming1,2; Li, Hong-Lei1,2; Konuklugil, Belma4; Wang, Bin-Gui1,2,5
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| 2020-04-13 | |
| Source Publication | NATURAL PRODUCT RESEARCH
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| ISSN | 1478-6419 |
| Pages | 6 |
| Corresponding Author | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| Abstract | A new austin-type meroterpene, namely, ustusaustin A (1), together with seven related known analogues (2-8), were isolated and identified from the culture extract ofAspergillus ustusTK-5, an endophytic fungus obtained from the marine ascidianPyura momus. The structures of these compounds were established on the basis of detailed interpretation of their NMR and MS data, and the relative and absolute configurations of1was confirmed by X-ray crystallographic analysis. Among them, ustusaustin A (1) represents the first example of 1'-nor-austin analogues with an unique 7-benzoylation. Compounds1-4,6, and7exhibited potent neuraminidase inhibitory activity and this is the first report of neuraminidase inhibitory activity for austin-type meroterpenes. |
| Keyword | Endophytic fungus Aspergillus ustus secondary metabolites neuraminidase inhibitory activity |
| DOI | 10.1080/14786419.2020.1752211 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | European Commission[PIRSESGA-2011-295226] ; National Natural Science Foundation of China-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; China Postdoctoral Science Foundation[2017M612360] ; Shandong Provincial Natural Science Foundation[ZR2017BB073] ; Taishan Scholar Project from Shandong Province of China |
| WOS Research Area | Chemistry ; Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Applied ; Chemistry, Medicinal |
| WOS ID | WOS:000560732300001 |
| Publisher | TAYLOR & FRANCIS LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/168286 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Wang, Bin-Gui |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China 4.Ankara Univ, Fac Pharm, Dept Pharmacognosy, Ankara, Turkey 5.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences; Center for Ocean Mega-Science, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Li, Xin,Li, Li,Li, Xiao-Ming,et al. Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5[J]. NATURAL PRODUCT RESEARCH,2020:6. |
| APA | Li, Xin,Li, Li,Li, Xiao-Ming,Li, Hong-Lei,Konuklugil, Belma,&Wang, Bin-Gui.(2020).Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5.NATURAL PRODUCT RESEARCH,6. |
| MLA | Li, Xin,et al."Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5".NATURAL PRODUCT RESEARCH (2020):6. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Ustusaustin A_ a new（1754KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View | |
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