Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5 | |
Li, Xin1,2 ; Li, Li1,3; Li, Xiao-Ming1,2; Li, Hong-Lei1,2; Konuklugil, Belma4; Wang, Bin-Gui1,2,5
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| 2020-04-13 | |
| 发表期刊 | NATURAL PRODUCT RESEARCH
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| ISSN | 1478-6419 |
| 页码 | 6 |
| 通讯作者 | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| 摘要 | A new austin-type meroterpene, namely, ustusaustin A (1), together with seven related known analogues (2-8), were isolated and identified from the culture extract ofAspergillus ustusTK-5, an endophytic fungus obtained from the marine ascidianPyura momus. The structures of these compounds were established on the basis of detailed interpretation of their NMR and MS data, and the relative and absolute configurations of1was confirmed by X-ray crystallographic analysis. Among them, ustusaustin A (1) represents the first example of 1'-nor-austin analogues with an unique 7-benzoylation. Compounds1-4,6, and7exhibited potent neuraminidase inhibitory activity and this is the first report of neuraminidase inhibitory activity for austin-type meroterpenes. |
| 关键词 | Endophytic fungus Aspergillus ustus secondary metabolites neuraminidase inhibitory activity |
| DOI | 10.1080/14786419.2020.1752211 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | European Commission[PIRSESGA-2011-295226] ; National Natural Science Foundation of China-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; China Postdoctoral Science Foundation[2017M612360] ; Shandong Provincial Natural Science Foundation[ZR2017BB073] ; Taishan Scholar Project from Shandong Province of China |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Applied ; Chemistry, Medicinal |
| WOS记录号 | WOS:000560732300001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/168286 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China 4.Ankara Univ, Fac Pharm, Dept Pharmacognosy, Ankara, Turkey 5.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 通讯作者单位 | 中国科学院海洋研究所; 中国科学院海洋大科学研究中心 |
| 推荐引用方式 GB/T 7714 | Li, Xin,Li, Li,Li, Xiao-Ming,et al. Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5[J]. NATURAL PRODUCT RESEARCH,2020:6. |
| APA | Li, Xin,Li, Li,Li, Xiao-Ming,Li, Hong-Lei,Konuklugil, Belma,&Wang, Bin-Gui.(2020).Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5.NATURAL PRODUCT RESEARCH,6. |
| MLA | Li, Xin,et al."Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5".NATURAL PRODUCT RESEARCH (2020):6. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Ustusaustin A_ a new（1754KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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