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Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5
Li, Xin1,2; Li, Li1,3; Li, Xiao-Ming1,2; Li, Hong-Lei1,2; Konuklugil, Belma4; Wang, Bin-Gui1,2,5
2020-04-13
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Pages6
Corresponding AuthorWang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractA new austin-type meroterpene, namely, ustusaustin A (1), together with seven related known analogues (2-8), were isolated and identified from the culture extract ofAspergillus ustusTK-5, an endophytic fungus obtained from the marine ascidianPyura momus. The structures of these compounds were established on the basis of detailed interpretation of their NMR and MS data, and the relative and absolute configurations of1was confirmed by X-ray crystallographic analysis. Among them, ustusaustin A (1) represents the first example of 1'-nor-austin analogues with an unique 7-benzoylation. Compounds1-4,6, and7exhibited potent neuraminidase inhibitory activity and this is the first report of neuraminidase inhibitory activity for austin-type meroterpenes.
KeywordEndophytic fungus Aspergillus ustus secondary metabolites neuraminidase inhibitory activity
DOI10.1080/14786419.2020.1752211
Indexed BySCI
Language英语
Funding ProjectEuropean Commission[PIRSESGA-2011-295226] ; National Natural Science Foundation of China-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; China Postdoctoral Science Foundation[2017M612360] ; Shandong Provincial Natural Science Foundation[ZR2017BB073] ; Taishan Scholar Project from Shandong Province of China
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Applied ; Chemistry, Medicinal
WOS IDWOS:000560732300001
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/168286
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China
4.Ankara Univ, Fac Pharm, Dept Pharmacognosy, Ankara, Turkey
5.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Xin,Li, Li,Li, Xiao-Ming,et al. Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5[J]. NATURAL PRODUCT RESEARCH,2020:6.
APA Li, Xin,Li, Li,Li, Xiao-Ming,Li, Hong-Lei,Konuklugil, Belma,&Wang, Bin-Gui.(2020).Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5.NATURAL PRODUCT RESEARCH,6.
MLA Li, Xin,et al."Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5".NATURAL PRODUCT RESEARCH (2020):6.
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