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The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses
Lv, Zhao1,2,3; Qiu, Limei1,3; Wang, Weilin4,5,6; Liu, Zhaoqun4,5,6; Liu, Qing1,3; Wang, Lingling4,5,6; Song, Linsheng4,5,6
2020-07-23
Source PublicationFRONTIERS IN IMMUNOLOGY
ISSN1664-3224
Volume11Pages:22
Corresponding AuthorQiu, Limei(qiulimei@qdio.ac.cn) ; Song, Linsheng(lshsong@dlou.edu.cn)
AbstractStudies on invertebrate immune receptors can provide insights into characteristics specific to innate immune system. Here, eight alpha and three beta integrins are identified from an invertebrate, the Pacific oysterCrassostrea gigas, and their possible immune functions are studied. Oyster alpha/beta integrins exhibit a higher degree of sequence and structural variability than the members fromHomo sapiensandDrosophila melanogaster. The analysis reveals that oyster RGD- and laminin-binding receptor homologs are present in the phylogenetic tree of alpha integrins, but the other six oyster alpha integrins mainly form a species-specific branch; meanwhile, oyster beta integrins are clustered with insect beta integrins but distinct from a member from the molluskBiomphalaria glabrata. Although phylogenetically lacking the important alpha integrin branches of LDV-binding, PS3-type, and alpha I-containing integrins, oyster integrins can bind to most ECM ligands, including RGDCP, LDVCP, GFOGERCP, and laminin protein in a distinct binding pattern. Besides, oyster integrins are distributed in different hemocyte subpopulations, while only specific integrins are selectively involved in hemocyte phagocytosis, migration, and encapsulation, and some of them participate in more than one immune response in a sophisticated pattern. Especially, oyster beta integrins are arranged in the core to mediate complex immune responses, unlike the counterparts in humans that mainly depend on alpha I-containing integrins to incite immune reactions. This study represents the first comprehensive attempt to reveal the structural and evolutionary features of the integrin family and their involvement in cellular immune responses in the non-model invertebrateC. gigasand sheds light on the characteristics specific to the innate immune system in the integrin family.
KeywordCrassostrea gigas integrin family immune function ECM ligand binding functional division and cooperation
DOI10.3389/fimmu.2020.01420
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31530069] ; Research Foundation for Talented Scholars in Dalian Ocean University ; Earmarked Fund from Modern Agro-Industry Technology Research System[CARS-49]
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000560065900001
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/168163
Collection实验海洋生物学重点实验室
Corresponding AuthorQiu, Limei; Song, Linsheng
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China
5.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol, Dalian, Peoples R China
6.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol & Dis Contro, Dalian, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Lv, Zhao,Qiu, Limei,Wang, Weilin,et al. The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses[J]. FRONTIERS IN IMMUNOLOGY,2020,11:22.
APA Lv, Zhao.,Qiu, Limei.,Wang, Weilin.,Liu, Zhaoqun.,Liu, Qing.,...&Song, Linsheng.(2020).The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses.FRONTIERS IN IMMUNOLOGY,11,22.
MLA Lv, Zhao,et al."The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses".FRONTIERS IN IMMUNOLOGY 11(2020):22.
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