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The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses
Lv, Zhao1,2,3; Qiu, Limei1,3; Wang, Weilin4,5,6; Liu, Zhaoqun4,5,6; Liu, Qing1,3; Wang, Lingling4,5,6; Song, Linsheng4,5,6
2020-07-23
发表期刊FRONTIERS IN IMMUNOLOGY
ISSN1664-3224
卷号11页码:22
通讯作者Qiu, Limei(qiulimei@qdio.ac.cn) ; Song, Linsheng(lshsong@dlou.edu.cn)
摘要Studies on invertebrate immune receptors can provide insights into characteristics specific to innate immune system. Here, eight alpha and three beta integrins are identified from an invertebrate, the Pacific oysterCrassostrea gigas, and their possible immune functions are studied. Oyster alpha/beta integrins exhibit a higher degree of sequence and structural variability than the members fromHomo sapiensandDrosophila melanogaster. The analysis reveals that oyster RGD- and laminin-binding receptor homologs are present in the phylogenetic tree of alpha integrins, but the other six oyster alpha integrins mainly form a species-specific branch; meanwhile, oyster beta integrins are clustered with insect beta integrins but distinct from a member from the molluskBiomphalaria glabrata. Although phylogenetically lacking the important alpha integrin branches of LDV-binding, PS3-type, and alpha I-containing integrins, oyster integrins can bind to most ECM ligands, including RGDCP, LDVCP, GFOGERCP, and laminin protein in a distinct binding pattern. Besides, oyster integrins are distributed in different hemocyte subpopulations, while only specific integrins are selectively involved in hemocyte phagocytosis, migration, and encapsulation, and some of them participate in more than one immune response in a sophisticated pattern. Especially, oyster beta integrins are arranged in the core to mediate complex immune responses, unlike the counterparts in humans that mainly depend on alpha I-containing integrins to incite immune reactions. This study represents the first comprehensive attempt to reveal the structural and evolutionary features of the integrin family and their involvement in cellular immune responses in the non-model invertebrateC. gigasand sheds light on the characteristics specific to the innate immune system in the integrin family.
关键词Crassostrea gigas integrin family immune function ECM ligand binding functional division and cooperation
DOI10.3389/fimmu.2020.01420
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[31530069] ; Research Foundation for Talented Scholars in Dalian Ocean University ; Earmarked Fund from Modern Agro-Industry Technology Research System[CARS-49]
WOS研究方向Immunology
WOS类目Immunology
WOS记录号WOS:000560065900001
出版者FRONTIERS MEDIA SA
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/168163
专题实验海洋生物学重点实验室
通讯作者Qiu, Limei; Song, Linsheng
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China
5.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol, Dalian, Peoples R China
6.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol & Dis Contro, Dalian, Peoples R China
第一作者单位中国科学院海洋研究所;  中国科学院海洋大科学研究中心
通讯作者单位中国科学院海洋研究所;  中国科学院海洋大科学研究中心
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GB/T 7714
Lv, Zhao,Qiu, Limei,Wang, Weilin,et al. The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses[J]. FRONTIERS IN IMMUNOLOGY,2020,11:22.
APA Lv, Zhao.,Qiu, Limei.,Wang, Weilin.,Liu, Zhaoqun.,Liu, Qing.,...&Song, Linsheng.(2020).The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses.FRONTIERS IN IMMUNOLOGY,11,22.
MLA Lv, Zhao,et al."The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses".FRONTIERS IN IMMUNOLOGY 11(2020):22.
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