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| Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480 | |
Meng, Ling-Hong1,2 ; Li, Xiao-Ming1,2; Li, Hong-Lei1,2; Wang, Bin-Gui1,2,3
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| 2020-07-01 | |
| 发表期刊 | MARINE DRUGS
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| 卷号 | 18期号:7页码:10 |
| 通讯作者 | Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| 摘要 | The co-cultivation of two or more different microbial strains in one culture vessel was supposed to be a viable experimental approach for enhancing the diversity of the compounds produced. Two new meroterpenoid derivatives, chermebilaenes A (1) and B (2), together with three known sesquiterpenoids, sesquicaranoic acid B (3), cyclonerodiol (4) and bisabol-l-on-13-sauremethylester (5), were characterized from a co-culture of the marine-derived fungal isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480. Neither fungus produced these compounds when cultured alone under the same conditions. Compound1represents an unprecedented acorane-type sesquiterpene hybridized with an octadecadienoic acid skeleton. The structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were assumed on the basis of acidic hydrolysis combined with modified Mosher's method and electronic circular dichroism (ECD) calculations. Compound1showed potent inhibitory activities againstCeratobasidium cornigerumandEdwardsiella tarda. |
| 关键词 | Penicillium chermesinum Penicillium bilaiae co-culture secondary metabolites antimicrobial activity |
| DOI | 10.3390/md18070339 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Natural Science Foundation of China[31600267] ; Natural Science Foundation of China[41976090] ; Qingdao National Laboratory for Marine Science and Technology[YQ2018NO08] ; project of Qingdao Science and Technology Bureau[18-2-2-59-jch] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017250] ; Taishan Scholar Project from Shandong Province |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal |
| WOS记录号 | WOS:000554187500001 |
| 出版者 | MDPI |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/168079 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Meng, Ling-Hong; Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 通讯作者单位 | 中国科学院海洋研究所; 中国科学院海洋大科学研究中心 |
| 推荐引用方式 GB/T 7714 | Meng, Ling-Hong,Li, Xiao-Ming,Li, Hong-Lei,et al. Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480[J]. MARINE DRUGS,2020,18(7):10. |
| APA | Meng, Ling-Hong,Li, Xiao-Ming,Li, Hong-Lei,&Wang, Bin-Gui.(2020).Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480.MARINE DRUGS,18(7),10. |
| MLA | Meng, Ling-Hong,et al."Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480".MARINE DRUGS 18.7(2020):10. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Chermebilaenes A and（895KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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