IOCAS-IR  > 实验海洋生物学重点实验室
Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299
Zhang, Fan-Zhong1,2; Li, Xiao-Ming1,2; Meng, Ling-Hong1,2; Wang, Bin-Gui1,2,3
2020-08-01
Source PublicationBIOORGANIC CHEMISTRY
ISSN0045-2068
Volume101Pages:6
Corresponding AuthorMeng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractA simple but previously undescribed macrolide with unprecedented bicyclo 5/9 ring system, namely, clado-cladosin A (1), along with two new sulfur-containing macrolides, namely, thiocladospolides F and G (2 and 3), were characterized from the mangrove-derived endophytic fungus Cladosporium cladosporioides MA-299. The structures of these compounds were established on the basis of spectroscopic interpretation, and the absolute configurations of compounds 1-3 were determined by X-ray crystallographic analysis, Mosher's method, and by a biogenetic point of view. The possible biogenetic pathway for compounds 1-3 as well as their congeners thiocladospolides A-D and pandangolide 3 was proposed, providing a role in distinguishing the position of sulfur substitution in thiomacrolides. Compounds 1-3 were evaluated for antimicrobial activities against human-, aquatic-, and plant-pathogenic microbes.
KeywordMangrove-derived Endophytic fungus Cladosporium cladosporioides Sulfur substitution Biogenetic pathway Antimicrobial activities
DOI10.1016/j.bioorg.2020.103950
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81673351] ; National Natural Science Foundation of China[31600267] ; Natural Science Foundation of Shandong Province[ZR2016BQ17] ; Taishan Scholar project from Shandong province
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Organic
WOS IDWOS:000552629800012
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/168033
Collection实验海洋生物学重点实验室
Corresponding AuthorMeng, Ling-Hong; Wang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Fan-Zhong,Li, Xiao-Ming,Meng, Ling-Hong,et al. Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299[J]. BIOORGANIC CHEMISTRY,2020,101:6.
APA Zhang, Fan-Zhong,Li, Xiao-Ming,Meng, Ling-Hong,&Wang, Bin-Gui.(2020).Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299.BIOORGANIC CHEMISTRY,101,6.
MLA Zhang, Fan-Zhong,et al."Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299".BIOORGANIC CHEMISTRY 101(2020):6.
Files in This Item:
File Name/Size DocType Version Access License
Cladocladosin A, an (1833KB)期刊论文出版稿开放获取CC BY-NC-SAView
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Fan-Zhong]'s Articles
[Li, Xiao-Ming]'s Articles
[Meng, Ling-Hong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Fan-Zhong]'s Articles
[Li, Xiao-Ming]'s Articles
[Meng, Ling-Hong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Fan-Zhong]'s Articles
[Li, Xiao-Ming]'s Articles
[Meng, Ling-Hong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Cladocladosin A, an unusual macrolide with bicyclo 5_9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.