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Effect of Fucoxanthin Administration on Thyroid Gland Injury Induced by Cadmium in Mice
Yang, Haoyue1,2; Xing, Ronge1,2; Liu, Song1,2; Li, Pengcheng1,2
2020-07-21
Source PublicationBIOLOGICAL TRACE ELEMENT RESEARCH
ISSN0163-4984
Pages8
AbstractThe intervention effect of fucoxanthin, which is reportedly a powerful antioxidant, on cadmium-induced thyroid damage in mice was evaluated. Animals (N= 120) were divided into control group (given pure water,N= 20) and CdCl2-exposed group (given CdCl(2)orally at a dose of 30 mg/kg body weight (bw)/day for 30 days,N= 100). Besides, the CdCl2-exposed group was divided into the following 5 groups (N= 20) to evaluate the intervention effect of fucoxanthin: (1) negative control group (NCG; animals were supplied with pure water); (2) positive control group (PCG; animals were supplied with 50 mg/kg bw/day thyroid tablets. Thyroid tablets are made from the thyroid glands of pigs, cattle, sheep and other food animals (the main components of T4). But because they are extracts of the thyroid glands, they may contain a small amount of T3. The specific amount of T3 is unknown.); (3) low fucoxanthin concentration group (F1; animals were supplied with 10 mg/kg bw/day fucoxanthin); (4) medium fucoxanthin concentration group (F2; animals were supplied with 25 mg/kg bw/day fucoxanthin); (5) high fucoxanthin concentration groups (F3; animals were supplied with 50 mg/kg bw/day fucoxanthin). A 14-day treatment was conducted for these animals. The levels of T4, T3, MDA, ascorbate peroxidase (APX) and catalase were measured, and the expression levels ofBax,Bcl-2,ERK1,ERK2,MEK1,eIf2 alpha,p-eIf2 alpha,GRP78andGRP94genes were determined using real-time reverse transcriptase-polymerase chain reactions (RT-PCR). In addition, tissue histopathology and ultrastructure were recorded and analysed. We found that the injection of cadmium chloride (CdCl2) decreased serum T4 and T3 levels to 27.10 ng/ml and 837.74 pg/ml, respectively. In addition, CdCl(2)intoxication induced oxidative stress, structural abnormalities and apoptosis in thyroid follicles. Our results showed that the treatment of CaCl-exposed mice with 25-50 mg/kg bw/day fucoxanthin appreciably decreased oxidative stress and apoptosis induced by CdCl(2)and restored the microstructural and ultrastructural organisations of the thyroid gland towards normalcy. Compared with the negative control group, fucoxanthin treatment groups showed significant increase in T4 and T3 levels (52.17 ng/ml and 1669.18 ng/ml, respectively;P< 0.05), relieved oxidative stress by decreasing malondialdehyde level and increasing catalase and APX levels and increased apoptosis inhibition through inhibiting the ERK1/2 pathway and preventing endoplasmic reticulum stress in thyroid follicular epithelial cells. Herein, our study provides evidence of the protective effects of fucoxanthin supplementation against thyroid damage and suggests therapeutic potential of this pigment in cases of Cd intoxication and hypothyroidism.
KeywordFucoxanthin Cadmium Thyrotoxicity Impaired thyroid function Anti-hypothyroidism
DOI10.1007/s12011-020-02291-9
Indexed BySCI
Language英语
Funding ProjectKey Research and Development Program of Shandong Province[2019GHY112015] ; Key Research and Development Program of Shandong Province[2017YYSP018] ; Qingdao 2016 marine economic innovation and development demonstration city project plan
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000550594700001
PublisherHUMANA PRESS INC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/168027
Collection实验海洋生物学重点实验室
Corresponding AuthorXing, Ronge
Affiliation1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yang, Haoyue,Xing, Ronge,Liu, Song,et al. Effect of Fucoxanthin Administration on Thyroid Gland Injury Induced by Cadmium in Mice[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2020:8.
APA Yang, Haoyue,Xing, Ronge,Liu, Song,&Li, Pengcheng.(2020).Effect of Fucoxanthin Administration on Thyroid Gland Injury Induced by Cadmium in Mice.BIOLOGICAL TRACE ELEMENT RESEARCH,8.
MLA Yang, Haoyue,et al."Effect of Fucoxanthin Administration on Thyroid Gland Injury Induced by Cadmium in Mice".BIOLOGICAL TRACE ELEMENT RESEARCH (2020):8.
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