Protective Effect of a Fucose-Rich Fucoidan Isolated fromSaccharina japonicaagainst Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish

doi:10.3390/md18060316

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	Protective Effect of a Fucose-Rich Fucoidan Isolated fromSaccharina japonicaagainst Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish
	Su, Wanchun 1; Wang, Lei 2,3; Fu, Xiaoting 1; Ni, Liying 1; Duan, Delin 4,5; Xu, Jiachao1 ; Gao, Xin 1
	2020-06-01
发表期刊	MARINE DRUGS
卷号	18 期号:6 页码:12
通讯作者	Fu, Xiaoting(xiaotingfu@ouc.edu.cn)
摘要	A fucose-rich fucoidan was purified from brown seaweedSaccharina japonica, of which the UVB protective effect was investigated in vitro in keratinocytes of HaCaT cells and in vivo in zebrafish. The intracellular reactive oxygen species levels and the viability of UVB-irradiated HaCaT cells were determined. The results indicate that the purified fucoidan significantly reduced the intracellular reactive oxygen species levels and improved the viability of UVB-irradiated HaCaT cells. Furthermore, the purified fucoidan remarkably decreased the apoptosis by regulating the expressions of Bax/Bcl-xL and cleaved caspase-3 in UVB-irradiated HaCaT cells in a dose-dependent manner. In addition, the in vivo UV protective effect of the purified fucoidan was investigated using a zebrafish model. It significantly reduced the intracellular reactive oxygen species level, the cell death, the NO production, and the lipid peroxidation in UVB-irradiated zebrafish in a dose-dependent manner. These results suggest that purified fucoidan has a great potential to be developed as a natural anti-UVB agent applied in the cosmetic industry.
关键词	ROS Phaeophyta carbohydrate UVB irradiation HaCaT cells zebrafish
DOI	10.3390/md18060316
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2018YFD0901104] ; Major Scientific and Technological Innovation Project of Shandong Province[2019JZZY020613]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000551180900034
出版者	MDPI
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/167979
专题	实验海洋生物学重点实验室
通讯作者	Fu, Xiaoting
作者单位	1.Ocean Univ China, Coll Food Sci & Engn, 5th Yushan Rd, Qingdao 266003, Peoples R China 2.Jeju Natl Univ, Dept Marine Life Sci, Jeju Si 63243, Jeju Self Gover, South Korea 3.Jeju Natl Univ, Marine Sci Inst, Jeju Si 63333, Jeju Self Gover, South Korea 4.State Key Lab Seaweed Bioact Subst, 1th Daxueyuan Rd, Qingdao 266400, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Su, Wanchun,Wang, Lei,Fu, Xiaoting,et al. Protective Effect of a Fucose-Rich Fucoidan Isolated fromSaccharina japonicaagainst Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish[J]. MARINE DRUGS,2020,18(6):12.
APA	Su, Wanchun.,Wang, Lei.,Fu, Xiaoting.,Ni, Liying.,Duan, Delin.,...&Gao, Xin.(2020).Protective Effect of a Fucose-Rich Fucoidan Isolated fromSaccharina japonicaagainst Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish.MARINE DRUGS,18(6),12.
MLA	Su, Wanchun,et al."Protective Effect of a Fucose-Rich Fucoidan Isolated fromSaccharina japonicaagainst Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish".MARINE DRUGS 18.6(2020):12.

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