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Protective Effect of a Fucose-Rich Fucoidan Isolated fromSaccharina japonicaagainst Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish
Su, Wanchun1; Wang, Lei2,3; Fu, Xiaoting1; Ni, Liying1; Duan, Delin4,5; Xu, Jiachao1; Gao, Xin1
2020-06-01
Source PublicationMARINE DRUGS
Volume18Issue:6Pages:12
Corresponding AuthorFu, Xiaoting(xiaotingfu@ouc.edu.cn)
AbstractA fucose-rich fucoidan was purified from brown seaweedSaccharina japonica, of which the UVB protective effect was investigated in vitro in keratinocytes of HaCaT cells and in vivo in zebrafish. The intracellular reactive oxygen species levels and the viability of UVB-irradiated HaCaT cells were determined. The results indicate that the purified fucoidan significantly reduced the intracellular reactive oxygen species levels and improved the viability of UVB-irradiated HaCaT cells. Furthermore, the purified fucoidan remarkably decreased the apoptosis by regulating the expressions of Bax/Bcl-xL and cleaved caspase-3 in UVB-irradiated HaCaT cells in a dose-dependent manner. In addition, the in vivo UV protective effect of the purified fucoidan was investigated using a zebrafish model. It significantly reduced the intracellular reactive oxygen species level, the cell death, the NO production, and the lipid peroxidation in UVB-irradiated zebrafish in a dose-dependent manner. These results suggest that purified fucoidan has a great potential to be developed as a natural anti-UVB agent applied in the cosmetic industry.
KeywordROS Phaeophyta carbohydrate UVB irradiation HaCaT cells zebrafish
DOI10.3390/md18060316
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFD0901104] ; Major Scientific and Technological Innovation Project of Shandong Province[2019JZZY020613]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000551180900034
PublisherMDPI
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/167979
Collection实验海洋生物学重点实验室
Corresponding AuthorFu, Xiaoting
Affiliation1.Ocean Univ China, Coll Food Sci & Engn, 5th Yushan Rd, Qingdao 266003, Peoples R China
2.Jeju Natl Univ, Dept Marine Life Sci, Jeju Si 63243, Jeju Self Gover, South Korea
3.Jeju Natl Univ, Marine Sci Inst, Jeju Si 63333, Jeju Self Gover, South Korea
4.State Key Lab Seaweed Bioact Subst, 1th Daxueyuan Rd, Qingdao 266400, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Su, Wanchun,Wang, Lei,Fu, Xiaoting,et al. Protective Effect of a Fucose-Rich Fucoidan Isolated fromSaccharina japonicaagainst Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish[J]. MARINE DRUGS,2020,18(6):12.
APA Su, Wanchun.,Wang, Lei.,Fu, Xiaoting.,Ni, Liying.,Duan, Delin.,...&Gao, Xin.(2020).Protective Effect of a Fucose-Rich Fucoidan Isolated fromSaccharina japonicaagainst Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish.MARINE DRUGS,18(6),12.
MLA Su, Wanchun,et al."Protective Effect of a Fucose-Rich Fucoidan Isolated fromSaccharina japonicaagainst Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish".MARINE DRUGS 18.6(2020):12.
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