Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Dimeric hexylitaconic acids from the marine-derived fungusAspergillus welwitschiaeCUGBMF180262 | |
| Han, Jiahui1,2; Yang, Na3,4; Wei, Shangzhu1; Jia, Jia5; Lin, Rui1; Li, Jiangpeng1; Bi, Hongkai5; Song, Fuhang2,6; Xu, Xiuli1 | |
| 2020-07-14 | |
| Source Publication | NATURAL PRODUCT RESEARCH
 |
| ISSN | 1478-6419 |
| Pages | 8 |
| Corresponding Author | Song, Fuhang(songfuhang@btbu.edu.cn) ; Xu, Xiuli(xuxl@cugb.edu.cn) |
| Abstract | In the course of our efforts to search new secondary metabolites from marine-derived fungi, one new hexylitaconic acid derivative, 3-(5-methoxycarbonylpentyl)-4-methylfuran-2,5-dione (1), and two dimeric analogues asperwelwinates A and B (2and3), together with ten known compounds, asperitaconic acid C (4), kotanin (5) and orlandin (6), desertorin B (7), fonsecinone A (8), aurasperone A (9), asperpyrones B and C (10 and11), aspernigrin B (12), and pyrophen (13), were isolated from a strain ofAspergillus welwitschiaeCUGBMF180262. The structures of compounds1-3were determined by detailed analysis of HRMS, and 1D/2D NMR experiments, while the absolute configurations of2and3were determined by comparison of experimental and calculated electronic circular dichroism spectra.2and3were first reported dimeric hexylitaconic acid derivatives. Compounds8,9and11showed moderate antibacterial activities againstHelicobacter pyloriwith minimum inhibitory concentration (MIC) values of 16 mu g/mL. |
| Keyword | Marine-derivedAspergillus welwitschiae dimeric hexylitaconic acid anti-Helicobacter pylori |
| DOI | 10.1080/14786419.2020.1793152 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2018YFC0311002] ; National Key Research and Development Program of China[2017YFD0201203] ; National Key Research and Development Program of China[2017YFC1601300] ; National Natural Science Foundation of China[81973204] |
| WOS Research Area | Chemistry ; Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Applied ; Chemistry, Medicinal |
| WOS ID | WOS:000548987500001 |
| Publisher | TAYLOR & FRANCIS LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/167964 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Song, Fuhang; Xu, Xiuli |
| Affiliation | 1.China Univ Geosci, Sch Ocean Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China 5.Nanjing Med Univ, Dept Modern Pathogen Biol, Jiangsu Key Lab Modern Pathogen Biol, Nanjing, Jiangsu, Peoples R China 6.Beijing Technol & Business Univ, Sch Light Ind, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Han, Jiahui,Yang, Na,Wei, Shangzhu,et al. Dimeric hexylitaconic acids from the marine-derived fungusAspergillus welwitschiaeCUGBMF180262[J]. NATURAL PRODUCT RESEARCH,2020:8. |
| APA | Han, Jiahui.,Yang, Na.,Wei, Shangzhu.,Jia, Jia.,Lin, Rui.,...&Xu, Xiuli.(2020).Dimeric hexylitaconic acids from the marine-derived fungusAspergillus welwitschiaeCUGBMF180262.NATURAL PRODUCT RESEARCH,8. |
| MLA | Han, Jiahui,et al."Dimeric hexylitaconic acids from the marine-derived fungusAspergillus welwitschiaeCUGBMF180262".NATURAL PRODUCT RESEARCH (2020):8. |
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