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New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388
Chi, Lu-Ping1,2,3; Li, Xiao-Ming1,2; Li, Xin1,2; Wang, Bin-Gui1,2,4
2020-07-20
Source PublicationCHEMISTRY & BIODIVERSITY
ISSN1612-1872
Pages7
AbstractTwo new antibacterial thiodiketopiperazine derivatives (TDKPs), 7-dehydroxyepicoccin H and 7-hydroxyeutypellazine F, along with seven known TDKP analogs, were isolated and identified fromEpicoccum nigrumSD-388, a deep-sea-sediment-derived fungus. The structures of these compounds were elucidated on the basis of detailed spectroscopic analysis. The absolute configuration of 7-dehydroxyepicoccin H was established by X-ray crystallographic analysis, while 7-hydroxyeutypellazine F was determined by ECD experiment and TDDFT-ECD calculation. The antibacterial activities against human and aquatic pathogens were evaluated. 7-Dehydroxyepicoccin H and 7-hydroxyeutypellazine F displayed inhibitory activities against aquatic pathogensVibrio vulnificus,V. alginolyticus, andEdwardsiella tarda, with MIC values ranging from 4.0 to 8.0 mu g/mL.
Keyworddeep sea-derived fungus Epicoccum nigrum thiodiketopiperazines antibacterial activity
DOI10.1002/cbdv.202000320
Indexed BySCI
Language英语
Funding ProjectStrategic Priority Research Program of the Chinese Academy of Sciences[XDA22050401] ; Shandong Provincial Natural Science Foundation[ZR2019ZD18] ; Basic Applied Research program of Qingdao[19-6-2-40-cg] ; National Major Science and Technology Infrastructure from the Chinese Academy of Sciences[KEXUE2018G28] ; Taishan Scholar Project from Shandong Province[ts201511060]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000550490700001
PublisherWILEY-V C H VERLAG GMBH
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/167952
Collection实验海洋生物学重点实验室
Corresponding AuthorLi, Xin; Wang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Yuquan Rd 19 A, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Chi, Lu-Ping,Li, Xiao-Ming,Li, Xin,et al. New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388[J]. CHEMISTRY & BIODIVERSITY,2020:7.
APA Chi, Lu-Ping,Li, Xiao-Ming,Li, Xin,&Wang, Bin-Gui.(2020).New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388.CHEMISTRY & BIODIVERSITY,7.
MLA Chi, Lu-Ping,et al."New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388".CHEMISTRY & BIODIVERSITY (2020):7.
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