IOCAS-IR  > 实验海洋生物学重点实验室
CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes
Luo, Jiao1; Hou, Yufei1; Xie, Mengyue1; Ma, Wanli1; Shi, Dayong2,3; Jiang, Bo2,4
2020-05-01
Source PublicationMARINE DRUGS
Volume18Issue:5Pages:13
Corresponding AuthorShi, Dayong(shidayong@sdu.edu.cn) ; Jiang, Bo(jiangbo@qdio.ac.cn)
Abstract3-bromo-4,5-Bis(2,3-dibromo-4,5-dihydroxybenzyl)-1,2-benzenediol (CYC31) is a bromophenol protein tyrosine phosphatase 1B (PTP1B) inhibitor isolated from the red alga Rhodomela confervoides. Here, the effect of CYC31 on the insulin signaling and fatty-acid-induced disorders in C2C12 myotubes was investigated. Molecular docking assay showed that CYC31 was embedded into the catalytic pocket of PTP1B. A cellular study found that CYC31 increased the activity of insulin signaling and promoted 2-NBDG uptake through GLUT4 translocation in C2C12 myotubes. Further studies showed that CYC31 ameliorated palmitate-induced insulin resistance in C2C12 myotubes. Moreover, CYC31 treatment significantly increased the mRNA expression of carnitine palmitoyltransferase 1B (CPT-1B) and fatty acid binding protein 3 (FABP3), which was tightly linked with fatty acid oxidation. These findings suggested that CYC31 could prevent palmitate-induce insulin resistance and could improve fatty acid oxidation through PTP1B inhibition.
KeywordCYC31 PTP1B inhibitor insulin resistance fatty acid oxidization
DOI10.3390/md18050267
Indexed BySCI
Language英语
Funding ProjectKey research and development project of Shandong province[2018GSF118208] ; NSFC-Shandong Joint Fund[U1706213]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000541031900008
PublisherMDPI
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/167802
Collection实验海洋生物学重点实验室
Corresponding AuthorShi, Dayong; Jiang, Bo
Affiliation1.Qingdao Univ, Sch Publ Hlth, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
3.Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Luo, Jiao,Hou, Yufei,Xie, Mengyue,et al. CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes[J]. MARINE DRUGS,2020,18(5):13.
APA Luo, Jiao,Hou, Yufei,Xie, Mengyue,Ma, Wanli,Shi, Dayong,&Jiang, Bo.(2020).CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes.MARINE DRUGS,18(5),13.
MLA Luo, Jiao,et al."CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes".MARINE DRUGS 18.5(2020):13.
Files in This Item:
File Name/Size DocType Version Access License
CYC31, A Natural Bro(2455KB)期刊论文出版稿开放获取CC BY-NC-SAView
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Luo, Jiao]'s Articles
[Hou, Yufei]'s Articles
[Xie, Mengyue]'s Articles
Baidu academic
Similar articles in Baidu academic
[Luo, Jiao]'s Articles
[Hou, Yufei]'s Articles
[Xie, Mengyue]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Luo, Jiao]'s Articles
[Hou, Yufei]'s Articles
[Xie, Mengyue]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.