Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes | |
Luo, Jiao1; Hou, Yufei1; Xie, Mengyue1; Ma, Wanli1; Shi, Dayong2,3; Jiang, Bo2,4 | |
2020-05-01 | |
Source Publication | MARINE DRUGS
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Volume | 18Issue:5Pages:13 |
Corresponding Author | Shi, Dayong(shidayong@sdu.edu.cn) ; Jiang, Bo(jiangbo@qdio.ac.cn) |
Abstract | 3-bromo-4,5-Bis(2,3-dibromo-4,5-dihydroxybenzyl)-1,2-benzenediol (CYC31) is a bromophenol protein tyrosine phosphatase 1B (PTP1B) inhibitor isolated from the red alga Rhodomela confervoides. Here, the effect of CYC31 on the insulin signaling and fatty-acid-induced disorders in C2C12 myotubes was investigated. Molecular docking assay showed that CYC31 was embedded into the catalytic pocket of PTP1B. A cellular study found that CYC31 increased the activity of insulin signaling and promoted 2-NBDG uptake through GLUT4 translocation in C2C12 myotubes. Further studies showed that CYC31 ameliorated palmitate-induced insulin resistance in C2C12 myotubes. Moreover, CYC31 treatment significantly increased the mRNA expression of carnitine palmitoyltransferase 1B (CPT-1B) and fatty acid binding protein 3 (FABP3), which was tightly linked with fatty acid oxidation. These findings suggested that CYC31 could prevent palmitate-induce insulin resistance and could improve fatty acid oxidation through PTP1B inhibition. |
Keyword | CYC31 PTP1B inhibitor insulin resistance fatty acid oxidization |
DOI | 10.3390/md18050267 |
Indexed By | SCI |
Language | 英语 |
Funding Project | Key research and development project of Shandong province[2018GSF118208] ; NSFC-Shandong Joint Fund[U1706213] |
WOS Research Area | Pharmacology & Pharmacy |
WOS Subject | Chemistry, Medicinal |
WOS ID | WOS:000541031900008 |
Publisher | MDPI |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.qdio.ac.cn/handle/337002/167802 |
Collection | 实验海洋生物学重点实验室 |
Corresponding Author | Shi, Dayong; Jiang, Bo |
Affiliation | 1.Qingdao Univ, Sch Publ Hlth, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China |
Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences; Center for Ocean Mega-Science, Chinese Academy of Sciences |
Recommended Citation GB/T 7714 | Luo, Jiao,Hou, Yufei,Xie, Mengyue,et al. CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes[J]. MARINE DRUGS,2020,18(5):13. |
APA | Luo, Jiao,Hou, Yufei,Xie, Mengyue,Ma, Wanli,Shi, Dayong,&Jiang, Bo.(2020).CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes.MARINE DRUGS,18(5),13. |
MLA | Luo, Jiao,et al."CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes".MARINE DRUGS 18.5(2020):13. |
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