Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480

doi:10.3390/md18040194

IOCAS-IR > 实验海洋生物学重点实验室

	Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480
	Hu, Xue-Yi1,2,3 ; Li, Xiao-Ming 1,2; Yang, Sui-Qun 1,2; Liu, Hui1 ; Meng, Ling-Hong1,2 ; Wang, Bin-Gui1,2,4
	2020-04-01
发表期刊	MARINE DRUGS
卷号	18 期号:4 页码:10
通讯作者	Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
摘要	Secondary metabolites obtained from marine-derived fungi are rich sources of drug candidates. Three new sesquiterpenoids, chermesiterpenoids A-C (1-3), along with four known alkaloids (4-7), were isolated and identified from the marine red algal-derived fungus Penicillium chermesinum EN-480. The structures of these new sesquiterpenoids were elucidated using detailed analysis of the NMR data and their relative configurations were elucidated using nuclear overhauser effect spectroscopy (NOESY) spectra as well as gauge-independent atomic orbital (GIAO) NMR shift calculations and DP4+ probability analysis. Their absolute configurations were determined using electronic circular dichroism (ECD) calculations and modified Mosher's method. Compounds 2 and 3 exhibited potent activities against human and aquatic pathogenic bacteria and plant pathogenic fungi.
关键词	Penicillium chermesinum algal-derived fungus sesquiterpenoid antimicrobial activity
DOI	10.3390/md18040194
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of China[31330009] ; Natural Science Foundation of China[31600267] ; Qingdao National Laboratory for Marine Science and Technology[YQ2018NO08] ; project of Qingdao Science and Technology Bureau[18-2-2-59-jch] ; Taishan Scholar Project from Shandong Province
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000533909300047
出版者	MDPI
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/167624
专题	实验海洋生物学重点实验室
通讯作者	Meng, Ling-Hong; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Hu, Xue-Yi,Li, Xiao-Ming,Yang, Sui-Qun,et al. Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480[J]. MARINE DRUGS,2020,18(4):10.
APA	Hu, Xue-Yi,Li, Xiao-Ming,Yang, Sui-Qun,Liu, Hui,Meng, Ling-Hong,&Wang, Bin-Gui.(2020).Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480.MARINE DRUGS,18(4),10.
MLA	Hu, Xue-Yi,et al."Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480".MARINE DRUGS 18.4(2020):10.

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