IOCAS-IR
Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males
Goncalves, Jimmy1; Wan, Yufeng1; Guo, Xiaoyan2; Rha, Kyoungsun1; LeBoeuf, Brigitte1; Zhang, Liusuo3; Estler, Kerolayne1; Garcia, L. Rene1
2020-04-24
Source PublicationISCIENCE
Volume23Issue:4Pages:46
Corresponding AuthorGarcia, L. Rene(rgarcia@bio.tamu.edu)
AbstractDysregulated metabolism accelerates reduced decision-making and locomotor ability during aging. To identify mechanisms for delaying behavioral decline, we investigated how C. elegans males sustain their copulatory behavior during early to mid-adulthood. We found that in mid-agedmales, gluco-/glyceroneogenesis, promoted by phosphoenolpyruvate carboxykinase (PEPCK), sustains competitive reproductive behavior. C. elegans' PEPCK paralogs, pck-1 and pck-2, increase in expression during the first 2 days of adulthood. Insufficient PEPCK expression correlates with reduced egl-2-encoded ether-a-go-go K+ channel expression and premature hyper-excitability of copulatory circuits. For copulation, pck-1 is required in neurons, whereas pck-2 is required in the epidermis. However, PCK-2 is more essential, because we found that epidermal PCK-2 likely supplements the copulation circuitry with fuel. We identified the subunit A of succinate dehydrogenase SDHA-1 as a potent modulator of PEPCK expression. We postulate that during mid-adulthood, reduction in mitochondrial physiology signals the upregulation of cytosolic PEPCK to sustain the male's energy demands.
DOI10.1016/j.isci.2020.100990
Indexed BySCI
Language英语
Funding ProjectNational Institutes of Health, Office of Research Infrastructure Programs[P40OD010440]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000528359400022
PublisherCELL PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/167621
Collection中国科学院海洋研究所
Corresponding AuthorGarcia, L. Rene
Affiliation1.Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA
2.Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94158 USA
3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Goncalves, Jimmy,Wan, Yufeng,Guo, Xiaoyan,et al. Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males[J]. ISCIENCE,2020,23(4):46.
APA Goncalves, Jimmy.,Wan, Yufeng.,Guo, Xiaoyan.,Rha, Kyoungsun.,LeBoeuf, Brigitte.,...&Garcia, L. Rene.(2020).Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males.ISCIENCE,23(4),46.
MLA Goncalves, Jimmy,et al."Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males".ISCIENCE 23.4(2020):46.
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