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Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males | |
Goncalves, Jimmy1; Wan, Yufeng1; Guo, Xiaoyan2; Rha, Kyoungsun1; LeBoeuf, Brigitte1; Zhang, Liusuo3; Estler, Kerolayne1; Garcia, L. Rene1 | |
2020-04-24 | |
发表期刊 | ISCIENCE |
卷号 | 23期号:4页码:46 |
通讯作者 | Garcia, L. Rene(rgarcia@bio.tamu.edu) |
摘要 | Dysregulated metabolism accelerates reduced decision-making and locomotor ability during aging. To identify mechanisms for delaying behavioral decline, we investigated how C. elegans males sustain their copulatory behavior during early to mid-adulthood. We found that in mid-agedmales, gluco-/glyceroneogenesis, promoted by phosphoenolpyruvate carboxykinase (PEPCK), sustains competitive reproductive behavior. C. elegans' PEPCK paralogs, pck-1 and pck-2, increase in expression during the first 2 days of adulthood. Insufficient PEPCK expression correlates with reduced egl-2-encoded ether-a-go-go K+ channel expression and premature hyper-excitability of copulatory circuits. For copulation, pck-1 is required in neurons, whereas pck-2 is required in the epidermis. However, PCK-2 is more essential, because we found that epidermal PCK-2 likely supplements the copulation circuitry with fuel. We identified the subunit A of succinate dehydrogenase SDHA-1 as a potent modulator of PEPCK expression. We postulate that during mid-adulthood, reduction in mitochondrial physiology signals the upregulation of cytosolic PEPCK to sustain the male's energy demands. |
DOI | 10.1016/j.isci.2020.100990 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Institutes of Health, Office of Research Infrastructure Programs[P40OD010440] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000528359400022 |
出版者 | CELL PRESS |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/167621 |
专题 | 中国科学院海洋研究所 |
通讯作者 | Garcia, L. Rene |
作者单位 | 1.Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA 2.Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94158 USA 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China |
推荐引用方式 GB/T 7714 | Goncalves, Jimmy,Wan, Yufeng,Guo, Xiaoyan,et al. Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males[J]. ISCIENCE,2020,23(4):46. |
APA | Goncalves, Jimmy.,Wan, Yufeng.,Guo, Xiaoyan.,Rha, Kyoungsun.,LeBoeuf, Brigitte.,...&Garcia, L. Rene.(2020).Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males.ISCIENCE,23(4),46. |
MLA | Goncalves, Jimmy,et al."Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males".ISCIENCE 23.4(2020):46. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
1-s2.0-S258900422030(8215KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 |
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