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Marine bacterial surfactin CS30-2 induced necrosis-like cell death in Huh7.5 liver cancer cells
Zhou Shengnan1; Liu Ge2,3; Wu Shimei1
2020-05-01
Source PublicationJOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN2096-5508
Volume38Issue:3Pages:826-833
Corresponding AuthorWu Shimei(shimeiwu2016@126.com)
AbstractMarine bacterial strain Bacillus sp. CS30 exhibited high anticancer activity against Huh7.5 human liver cancer. We purified the corresponding anticancer agent by sequential acidic precipitation, methanol extraction, Sephadex LH-20 chromatography, and reversed phase high-performance liquid chromatography (RP-HPLC), then analyzed it in mass spectrometry. Based on the results of purification and mass spectrometry, we deduced that the anticancer agent was the same component as our previously purified antifungal agent surfactin CS30-2. However, to the best of our knowledge, this is the first report on the surfactin possessing both antifungal and anticancer activities. Surfactin CS30-2 was demonstrated to exhibit high anticancer activity in a dose-dependent manner against Huh7.5 liver cancer cells. Further investigation showed that surfactin CS30-2 induced the increased generation of reactive oxygen species (ROS) and severe disruption of cell membrane, thus leading to cell death. However, unlike previously reported surfactins, surfactin CS30-2 caused cancer cell death via necrosis instead of apoptosis.
KeywordBacillus surfactin anticancer activity reactive oxygen species (ROS)
DOI10.1007/s00343-019-9129-2
Indexed BySCI
Language英语
WOS Research AreaMarine & Freshwater Biology ; Oceanography
WOS SubjectLimnology ; Oceanography
WOS IDWOS:000536606000020
PublisherSCIENCE PRESS
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Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/167558
Collection实验海洋生物学重点实验室
Corresponding AuthorWu Shimei
Affiliation1.Qingdao Univ, Coll Life Sci, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Zhou Shengnan,Liu Ge,Wu Shimei. Marine bacterial surfactin CS30-2 induced necrosis-like cell death in Huh7.5 liver cancer cells[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2020,38(3):826-833.
APA Zhou Shengnan,Liu Ge,&Wu Shimei.(2020).Marine bacterial surfactin CS30-2 induced necrosis-like cell death in Huh7.5 liver cancer cells.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,38(3),826-833.
MLA Zhou Shengnan,et al."Marine bacterial surfactin CS30-2 induced necrosis-like cell death in Huh7.5 liver cancer cells".JOURNAL OF OCEANOLOGY AND LIMNOLOGY 38.3(2020):826-833.
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