Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan

doi:10.1016/j.ijbiomac.2013.05.023

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	Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan
	Qin, Yukun 1; Liu, Song 1; Xing, Ronge1 ; Li, Kecheng 1,2; Yu, Huahua1 ; Li, Pengcheng1 ; Xing, RG
	2013-10-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	61 页码:58-62
文章类型	Article
摘要	With an aim to discover novel chitosan derivatives with significant activities against crop-threatening fungi, (1,2,3-triazol-4-yl)methyl nicotinate chitosan (TAMNCS) was prepared via azide-alkyne click reaction. Its structure was characterized by FT-IR, H-1 NMR, elemental analysis, DSC, and SEM. In vitro antifungal properties of TAMNCS against Rhizoctonia solani Kuhn (R. solani), Stemphylium solani weber (S. solani), and Alternaria porri (A. porri) were studied at the concentrations ranged from 0.25 mg/mL to 1.0 mg/mL. Experiments conducted displayed the derivative had obviously enhanced antifungal activity after chemical modification compared with original chitosan. Moreover, it was shown that TAMNCS can 94.2% inhibit growth of A. pouf at 1.0 mg/mL, while dose at which the fungicide triadimefon had lower inhibitory index (62.2%). The primary antifungal results described here indicate this derivative may be a promising candidate as an antifungal agent. (C). 2013 Elsevier B.V. All rights reserved.; With an aim to discover novel chitosan derivatives with significant activities against crop-threatening fungi, (1,2,3-triazol-4-yl)methyl nicotinate chitosan (TAMNCS) was prepared via azide-alkyne click reaction. Its structure was characterized by FT-IR, H-1 NMR, elemental analysis, DSC, and SEM. In vitro antifungal properties of TAMNCS against Rhizoctonia solani Kuhn (R. solani), Stemphylium solani weber (S. solani), and Alternaria porri (A. porri) were studied at the concentrations ranged from 0.25 mg/mL to 1.0 mg/mL. Experiments conducted displayed the derivative had obviously enhanced antifungal activity after chemical modification compared with original chitosan. Moreover, it was shown that TAMNCS can 94.2% inhibit growth of A. pouf at 1.0 mg/mL, while dose at which the fungicide triadimefon had lower inhibitory index (62.2%). The primary antifungal results described here indicate this derivative may be a promising candidate as an antifungal agent. (C). 2013 Elsevier B.V. All rights reserved.
关键词	Chitosan Click Reaction 1 Characterization 2 Antifungal Activity 3-triazole
学科领域	Biochemistry & Molecular Biology
DOI	10.1016/j.ijbiomac.2013.05.023
URL	查看原文
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000326660700009
WOS关键词	CLICK CHEMISTRY ; CARBOXYMETHYL CHITOSAN ; THIOUREA DERIVATIVES ; CHITIN
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/16724
专题	海洋生物技术研发中心海洋环境工程技术研究发展中心
通讯作者	Xing, RG
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Qin, Yukun,Liu, Song,Xing, Ronge,et al. Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2013,61:58-62.
APA	Qin, Yukun.,Liu, Song.,Xing, Ronge.,Li, Kecheng.,Yu, Huahua.,...&Xing, RG.(2013).Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,61,58-62.
MLA	Qin, Yukun,et al."Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 61(2013):58-62.

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