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Anti-complementary activity of a degraded sulfated heterogalactan from red alga Pyropia haitanensis
Zhang, Zhongshan1; Wang, Xiaomei1; Lv, Fang2; Xie, Xiaochao3; Zhang, Shaoyong1; Cai, Chuner4; Jia, Rui4; Pan, Yongliang1; Liu, Feng5
2020-03-15
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume147Pages:527-533
Corresponding AuthorZhang, Zhongshan(01959@zjhu.edu.cn)
AbstractA sulfated galactan LP-G2 was isolated and purified from red alga, Pyropia hailanensis. It was a branched polysaccharide with average molecular weight about 8381 Da, composed of Gal, Glc, GalA and Ara. The structure of LP-G2 was determined using IR and NMR spectroscopy. It was composed of -> 4)-beta-D-galactose -> 4)-alpha-L-galactose-6-sulfate segments, with beta-D-Gk and alpha-D-galactose unit substituted at the &position of alpha-L-galactose. Functional analysis showed that LP-G2 inhibited complement activation on both the classic and alternative pathways with CH50 value of 3.08 = 025 mg/mL and AP(50) value of 223 +/- 020 mg/ml, respectively. Preliminary mechanism studies by using complement component depleted-sera indicated that LP-G2 selectively interacts with C1q, C2, C4 and C9. The results suggested that LP-G2 could be of potential benefits in treatment of the complement associated diseases. (C) 2020 Elsevier B.V. All rights reserved.
KeywordSulfated heterogalactan Pyropia haitanensis Anti-complementary
DOI10.1016/j.ijbiomac.2020.01.045
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31700307] ; National Natural Science Foundation of China[41876165] ; National Natural Science Foundation of China[31672295] ; Science and Technology Project of Huzhou[2017ZD2017] ; Shandong Agriculture Breeding Engineering Biological Resources Innovation of Research Project[2017LZN013] ; Key Laboratory for Chemistry of Traditional Chinese Medicine[10Y201702] ; Key Research Program of Frontier Sciences, Chinese Academy of Sciences[QYZDB-SSW-DQC023]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000525864700057
PublisherELSEVIER
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/167218
Collection海洋生态与环境科学重点实验室
Corresponding AuthorZhang, Zhongshan
Affiliation1.Huzhou Univ, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou 313000, Peoples R China
2.Marine Biol Inst Shandong Prov, Qingdao 266104, Peoples R China
3.Hiser Med Ctr Qingdao, Shandong 266033, Peoples R China
4.Shanghai Ocean Univ, Coll Marine Ecol & Environm, Shanghai 201306, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Zhongshan,Wang, Xiaomei,Lv, Fang,et al. Anti-complementary activity of a degraded sulfated heterogalactan from red alga Pyropia haitanensis[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,147:527-533.
APA Zhang, Zhongshan.,Wang, Xiaomei.,Lv, Fang.,Xie, Xiaochao.,Zhang, Shaoyong.,...&Liu, Feng.(2020).Anti-complementary activity of a degraded sulfated heterogalactan from red alga Pyropia haitanensis.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,147,527-533.
MLA Zhang, Zhongshan,et al."Anti-complementary activity of a degraded sulfated heterogalactan from red alga Pyropia haitanensis".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 147(2020):527-533.
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