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Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection
Ji, Liqin1,2,3,4; Sun, Guoxiang1; Li, Xian1,2,4; Liu, Ying2,5
2020-03-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume98Pages:87-99
Corresponding AuthorLiu, Ying(yingliu@dlou.edu.cn)
AbstractTo study the mechanism of beta-glucan in immune protection, rainbow trout were fed diets with or without 0.2% beta-glucan for 42 days and then infected with Aeromonas sabnonicida. After that, spleen tissues were sampled on 4-and 6-days post infection (dpi). Transcriptome analysis was compared between control group (CG, without beta-glucan addition) and 0.2% beta-glucan group (BG). In CG vs BG, 378 and 406 DEGs were identified on 4 dpi and 6 dpi respectively; furthermore, 46 DEGs were shared on 4 dpi and 6 dpi, enriching in GO terms, such as complement activation, inflammatory response, and metabolic process. KEGG pathway analysis revealed that some DEGs in CG vs BG were involved in immune or metabolic signaling pathways such as complement and coagulation cascades, toll-like receptor signaling pathway, NF-kappa B signaling pathway, antigen processing and presentation, and platelet activation on 4 or 6 dpi. DEGs, such as fgg, fgb, f5, c9, c3, c5, dry, and myd88, were analyzed in CG vs BG on 4 dpi and 6 dpi, implying their potential roles in beta-glucan-modulated immunity. These results are beneficial to understand the mechanism of beta-glucan in resisting bacteria in fish.
Keywordbeta-glucan Rainbow trout Transcriptome Spleen Aeromonas salmonicida
DOI10.1016/j.fsi.2019.12.022
Indexed BySCI
Language英语
Funding ProjectNational Key Technologies RD Program[2017YFB0404000] ; Key R&D Program of Guangdong Province[2019B020215001] ; National Natural Science Foundation of China[31672673] ; Key Technologies R&D Program of Shandong Province[2018GHY115031]
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000516880900010
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/167118
Collection实验海洋生物学重点实验室
Corresponding AuthorLiu, Ying
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266235, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
5.Dalian Ocean Univ, Sch Marine Sci & Environm Engn, Dalian 116023, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Ji, Liqin,Sun, Guoxiang,Li, Xian,et al. Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection[J]. FISH & SHELLFISH IMMUNOLOGY,2020,98:87-99.
APA Ji, Liqin,Sun, Guoxiang,Li, Xian,&Liu, Ying.(2020).Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection.FISH & SHELLFISH IMMUNOLOGY,98,87-99.
MLA Ji, Liqin,et al."Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection".FISH & SHELLFISH IMMUNOLOGY 98(2020):87-99.
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