Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection | |
Ji, Liqin1,2,3,4; Sun, Guoxiang1; Li, Xian1,2,4; Liu, Ying2,5
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| 2020-03-01 | |
| 发表期刊 | FISH & SHELLFISH IMMUNOLOGY
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| ISSN | 1050-4648 |
| 卷号 | 98页码:87-99 |
| 通讯作者 | Liu, Ying(yingliu@dlou.edu.cn) |
| 摘要 | To study the mechanism of beta-glucan in immune protection, rainbow trout were fed diets with or without 0.2% beta-glucan for 42 days and then infected with Aeromonas sabnonicida. After that, spleen tissues were sampled on 4-and 6-days post infection (dpi). Transcriptome analysis was compared between control group (CG, without beta-glucan addition) and 0.2% beta-glucan group (BG). In CG vs BG, 378 and 406 DEGs were identified on 4 dpi and 6 dpi respectively; furthermore, 46 DEGs were shared on 4 dpi and 6 dpi, enriching in GO terms, such as complement activation, inflammatory response, and metabolic process. KEGG pathway analysis revealed that some DEGs in CG vs BG were involved in immune or metabolic signaling pathways such as complement and coagulation cascades, toll-like receptor signaling pathway, NF-kappa B signaling pathway, antigen processing and presentation, and platelet activation on 4 or 6 dpi. DEGs, such as fgg, fgb, f5, c9, c3, c5, dry, and myd88, were analyzed in CG vs BG on 4 dpi and 6 dpi, implying their potential roles in beta-glucan-modulated immunity. These results are beneficial to understand the mechanism of beta-glucan in resisting bacteria in fish. |
| 关键词 | beta-glucan Rainbow trout Transcriptome Spleen Aeromonas salmonicida |
| DOI | 10.1016/j.fsi.2019.12.022 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Key Technologies RD Program[2017YFB0404000] ; Key R&D Program of Guangdong Province[2019B020215001] ; National Natural Science Foundation of China[31672673] ; Key Technologies R&D Program of Shandong Province[2018GHY115031] |
| WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| WOS类目 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| WOS记录号 | WOS:000516880900010 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/167118 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Liu, Ying |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266235, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 5.Dalian Ocean Univ, Sch Marine Sci & Environm Engn, Dalian 116023, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室; 中国科学院海洋大科学研究中心 |
| 推荐引用方式 GB/T 7714 | Ji, Liqin,Sun, Guoxiang,Li, Xian,et al. Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection[J]. FISH & SHELLFISH IMMUNOLOGY,2020,98:87-99. |
| APA | Ji, Liqin,Sun, Guoxiang,Li, Xian,&Liu, Ying.(2020).Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection.FISH & SHELLFISH IMMUNOLOGY,98,87-99. |
| MLA | Ji, Liqin,et al."Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection".FISH & SHELLFISH IMMUNOLOGY 98(2020):87-99. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Comparative transcri（3117KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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