IOCAS-IR
An acid-tolerance response system protecting exponentially growing Escherichia coli
Xu, Ying1,2; Zhao, Zhe1,2; Tong, Wenhua1,7; Ding, Yamei3; Liu, Bin4; Shi, Yixin5; Wang, Jichao1; Sun, Shenmei1,2; Liu, Min1; Wang, Yuhui4; Qi, Qingsheng6; Xian, Mo1; Zhao, Guang1,6
2020-03-20
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume11Issue:1Pages:13
Corresponding AuthorXian, Mo(xianmo@qibebt.ac.cn) ; Zhao, Guang(zhaoguang@qibebt.ac.cn)
AbstractThe ability to grow at moderate acidic conditions (pH 4.0-5.0) is important to Escherichia coli colonization of the host's intestine. Several regulatory systems are known to control acid resistance in E. coli, enabling the bacteria to survive under acidic conditions without growth. Here, we characterize an acid-tolerance response (ATR) system and its regulatory circuit, required for E. coli exponential growth at pH 4.2. A two-component system CpxRA directly senses acidification through protonation of CpxA periplasmic histidine residues, and upregulates the fabA and fabB genes, leading to increased production of unsaturated fatty acids. Changes in lipid composition decrease membrane fluidity, F0F1-ATPase activity, and improve intracellular pH homeostasis. The ATR system is important for E. coli survival in the mouse intestine and for production of higher level of 3-hydroxypropionate during fermentation. Furthermore, this ATR system appears to be conserved in other Gram-negative bacteria. The ability to grow at acidic pH is crucial for E. coli colonization of the host's intestine. Here, the authors identify an acid-tolerance response system that is important for E. coli exponential growth at pH 4.2, survival in the mouse intestine, and production of 3-hydroxypropionate during fermentation.
DOI10.1038/s41467-020-15350-5
Indexed BySCI
Language英语
Funding ProjectNSFC[31722001] ; NSFC[31670089] ; Natural Science Foundation of Shandong Province[JQ201707]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000522096100016
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/167103
Collection中国科学院海洋研究所
Corresponding AuthorXian, Mo; Zhao, Guang
Affiliation1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
4.Nankai Univ, TEDA, TEDA Inst Biol Sci & Biotechnol, Tianjin 300457, Peoples R China
5.Arizona State Univ, Sch Life Sci, Tempe, AZ 85281 USA
6.Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China
7.Sichuan Univ Sci & Engn, Yibin 644000, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Xu, Ying,Zhao, Zhe,Tong, Wenhua,et al. An acid-tolerance response system protecting exponentially growing Escherichia coli[J]. NATURE COMMUNICATIONS,2020,11(1):13.
APA Xu, Ying.,Zhao, Zhe.,Tong, Wenhua.,Ding, Yamei.,Liu, Bin.,...&Zhao, Guang.(2020).An acid-tolerance response system protecting exponentially growing Escherichia coli.NATURE COMMUNICATIONS,11(1),13.
MLA Xu, Ying,et al."An acid-tolerance response system protecting exponentially growing Escherichia coli".NATURE COMMUNICATIONS 11.1(2020):13.
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