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Physiological responses to cold and starvation stresses in the liver of yellow drum (Nibea albiflora) revealed by LC-MS metabolomics
Jiao, Shuang1,2; Nie, Miaomiao1,2,3; Song, Hongbin4; Xu, Dongdong4; You, Feng1,2
2020-05-01
发表期刊SCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
卷号715页码:15
通讯作者Xu, Dongdong(xudong0580@163.com) ; You, Feng(youfeng@qdio.ac.cn)
摘要As global climate changes, mass mortality in farmed fish associated with the severely cold weather has aroused growing concerns. Yellow drum (Nibea albijiora) is an important maricultured fish in China, whereby its aquaculture suffered from overwinter mortality associated with cold and cold-induced-fasting stresses. Here, by using LC-MS metabolomics combined with transcriptomics, we investigated the physiological responses of yellow drum liver to cold and starvation stresses. The experiment involved four groups: 16 degrees C fed group (CG1), 16 degrees C unfed group (CG2), 8 degrees C fed group (EG1), and 8 degrees C unfed group (EG2). Under cold stress, a total of 308 and 257 differential metabolites were identified in EG1 vs. CG 1 and EG2 vs. CG2, respectively, showing 5 overlapping significant pathways: glutathione metabolism, biosynthesis of unsaturated fatty adds, galactose metabolism, arginine and proline metabolism, and ABC transporters. Intersection analysis identified that glutamate, oxidized glutathione (GSSG), and eicosenoic acid were the common metabolites induced by cold stress. Under starvation stress, a total of 300 and 215 differential metabolites were identified in CG2 vs. CG1 and EG2 vs. EG1, respectively, showing 2 overlapping significant pathways: glutathione metabolism and galactose metabolism. Intersection analysis revealed that glutamate and GSSG were the common metabolites caused by fasting. Under cold and starvation combined stresses, 286 differential metabolites were identified in EG2 vs. CG1, showing 7 influenced pathways: glycerophospholipid metabolism, biosynthesis of unsaturated fatty acids, glutathione metabolism, sphingolipid metabolism, glycosylphosphatidylinositol (GPI)-anchor biosynthesis, autophagy, and purine metabolism. Interestingly, the glutamate and GSSG were induced by both single and combined stresses of cold and starvation treatments. These findings suggest that glutathione metabolism and its related metabolites (glutamate and GSSG) could be potential biomarkers of cold and starvation stresses in yellow drum. Overall, the results of this study provided insights into the physiological regulation in response to cold and starvation stresses in this fish. (C) 2020 Published by Elsevier B.V.
关键词Nibea albiflora Low temperature Starvation Metabolomics Liver
DOI10.1016/j.scitotenv.2020.136940
收录类别SCI
语种英语
资助项目Project of Zhejiang Province of China[2017C04003] ; National Natural Science Foundation of China[41476127] ; National Natural Science Foundation of China[31502146] ; National Infrastructure of Fishery Germplasm Resource[2017DKA30470] ; Key Research and Development Program of Shandong Province, China[2019GHY112007]
WOS研究方向Environmental Sciences & Ecology
WOS类目Environmental Sciences
WOS记录号WOS:000518409900110
出版者ELSEVIER
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被引频次:60[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/165880
专题实验海洋生物学重点实验室
通讯作者Xu, Dongdong; You, Feng
作者单位1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Beijing 10049, Peoples R China
4.Marine Fishery Inst Zhejiang Prov, Key Lab Mariculture & Enhancement Zhejiang Prov, Zhoushan 316100, Peoples R China
第一作者单位中国科学院海洋大科学研究中心
通讯作者单位中国科学院海洋大科学研究中心
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Jiao, Shuang,Nie, Miaomiao,Song, Hongbin,et al. Physiological responses to cold and starvation stresses in the liver of yellow drum (Nibea albiflora) revealed by LC-MS metabolomics[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,715:15.
APA Jiao, Shuang,Nie, Miaomiao,Song, Hongbin,Xu, Dongdong,&You, Feng.(2020).Physiological responses to cold and starvation stresses in the liver of yellow drum (Nibea albiflora) revealed by LC-MS metabolomics.SCIENCE OF THE TOTAL ENVIRONMENT,715,15.
MLA Jiao, Shuang,et al."Physiological responses to cold and starvation stresses in the liver of yellow drum (Nibea albiflora) revealed by LC-MS metabolomics".SCIENCE OF THE TOTAL ENVIRONMENT 715(2020):15.
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