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Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications
Qin, Yukun1,2; Li, Pengcheng1,2; Guo, Zhanyong3
2020-05-15
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume236Pages:17
Corresponding AuthorLi, Pengcheng(pcli@qdio.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com)
AbstractThe increasing resistance of pathogen fungi poses a global public concern. There are several limitations in current antifungals, including few available fungicides, severe toxicity of some fungicides, and drug resistance. Therefore, there is an urgent need to develop new antifungals with novel targets. Chitosan has been recognized as a potential antifungal substance due to its good biocompatibility, biodegradability, non-toxicity, and availability in abundance, but its applications are hampered by the low charge density results in low solubility at physiological pH. It is believed that enhancing the positive charge density of chitosan may be the most effective approach to improve both its solubility and antifungal activity. Hence, this review mainly focuses on the structural optimization strategy of cationic chitosan and the potential antifungal applications. This review also assesses and comments on the challenges, shortcomings, and prospect of cationic chitosan derivatives as antifungal therapy.
KeywordCationic chitosan derivatives Antifungals Structural optimization strategy Antifungal therapy
DOI10.1016/j.carbpol.2020.116002
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFC0311305] ; National Key R&D Program of China[2019YFD0900705] ; Key Research and Development Program of Shandong Province[2018GHY115017] ; Qingdao Applied Basic Research Project[19-6-2-34-cg] ; Science and technology program of Nantong[MS120170234]
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000519306900012
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/165871
Collection实验海洋生物学重点实验室
Corresponding AuthorLi, Pengcheng; Guo, Zhanyong
Affiliation1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Qin, Yukun,Li, Pengcheng,Guo, Zhanyong. Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications[J]. CARBOHYDRATE POLYMERS,2020,236:17.
APA Qin, Yukun,Li, Pengcheng,&Guo, Zhanyong.(2020).Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications.CARBOHYDRATE POLYMERS,236,17.
MLA Qin, Yukun,et al."Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications".CARBOHYDRATE POLYMERS 236(2020):17.
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