Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44 | |
Li, Chun-Shun1; Li, Xiao-Ming1; Gao, Shu-Shan1; Lu, Yan-Hua2; Wang, Bin-Gui1; Wang, BG | |
2013-08-01 | |
发表期刊 | MARINE DRUGS |
ISSN | 1660-3397 |
卷号 | 11期号:8页码:3068-3076 |
文章类型 | Article |
摘要 | Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.; Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line. |
关键词 | Marine Fungus Sediment Anthranilic Acid Penicillium Paneum Cytotoxicity |
学科领域 | Pharmacology & Pharmacy |
DOI | 10.3390/md11083068 |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Pharmacology & Pharmacy |
WOS类目 | Chemistry, Medicinal |
WOS记录号 | WOS:000330521300024 |
WOS关键词 | NATURAL-PRODUCTS ; ANTIBACTERIAL ; METABOLITE ; INHIBITORS ; COMPLEXES ; ALKALOIDS |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/16556 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Wang, BG |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China |
第一作者单位 | 实验海洋生物学重点实验室 |
推荐引用方式 GB/T 7714 | Li, Chun-Shun,Li, Xiao-Ming,Gao, Shu-Shan,et al. Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44[J]. MARINE DRUGS,2013,11(8):3068-3076. |
APA | Li, Chun-Shun,Li, Xiao-Ming,Gao, Shu-Shan,Lu, Yan-Hua,Wang, Bin-Gui,&Wang, BG.(2013).Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44.MARINE DRUGS,11(8),3068-3076. |
MLA | Li, Chun-Shun,et al."Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44".MARINE DRUGS 11.8(2013):3068-3076. |
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