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Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44
Li, Chun-Shun1; Li, Xiao-Ming1; Gao, Shu-Shan1; Lu, Yan-Hua2; Wang, Bin-Gui1; Wang, BG
2013-08-01
发表期刊MARINE DRUGS
ISSN1660-3397
卷号11期号:8页码:3068-3076
文章类型Article
摘要Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.; Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.
关键词Marine Fungus Sediment Anthranilic Acid Penicillium Paneum Cytotoxicity
学科领域Pharmacology & Pharmacy
DOI10.3390/md11083068
URL查看原文
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000330521300024
WOS关键词NATURAL-PRODUCTS ; ANTIBACTERIAL ; METABOLITE ; INHIBITORS ; COMPLEXES ; ALKALOIDS
WOS标题词Science & Technology ; Life Sciences & Biomedicine
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被引频次:50[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/16556
专题实验海洋生物学重点实验室
通讯作者Wang, BG
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
第一作者单位实验海洋生物学重点实验室
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Li, Chun-Shun,Li, Xiao-Ming,Gao, Shu-Shan,et al. Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44[J]. MARINE DRUGS,2013,11(8):3068-3076.
APA Li, Chun-Shun,Li, Xiao-Ming,Gao, Shu-Shan,Lu, Yan-Hua,Wang, Bin-Gui,&Wang, BG.(2013).Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44.MARINE DRUGS,11(8),3068-3076.
MLA Li, Chun-Shun,et al."Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44".MARINE DRUGS 11.8(2013):3068-3076.
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