Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192 | |
Sun Hong1,2; Gao Shushan1,2; Li Xiaoming1; Li Chunshun1; Wang Bingui1; Wang, BG | |
2013-03-01 | |
发表期刊 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY |
ISSN | 0254-4059 |
卷号 | 31期号:2页码:464-470 |
文章类型 | Article |
摘要 | A chemical investigation of the ethyl acetate extract of the fermentation broth of Alternaria tenuissima EN-192, an endophytic fungus obtained from the stems of the marine mangrove plant Rhizophora stylosa, resulted in the isolation of nine known secondary metabolites, including four indole-diterpenoids: penijanthine A (1), paspaline (2), paspalinine (3), and penitrem A (4); three tricycloalternarene derivatives: tricycloalternarene 3a (5), tricycloalternarene 1b (6), and tricycloalternarene 2b (7); and two alternariol congeners: djalonensone (8) and alternariol (9). The chemical structures of these metabolites were characterized through a combination of detailed spectroscopic analyses and their comparison with reports from the literature. The inhibitory activities of each isolated compound against four bacteria were evaluated and compounds 5 and 8 displayed moderate activity against the aquaculture pathogenic bacterium Vibrio anguillarum, with inhibition zone diameters of 8 and 9 mm, respectively, at 100 mu g/disk. To the best of our knowledge, this is the first report on the secondary metabolites of mangrove-derived A lternaria tenuissima and also the first report of the isolation of indole-diterpenoids from fungal genus Alternaria.; A chemical investigation of the ethyl acetate extract of the fermentation broth of Alternaria tenuissima EN-192, an endophytic fungus obtained from the stems of the marine mangrove plant Rhizophora stylosa, resulted in the isolation of nine known secondary metabolites, including four indole-diterpenoids: penijanthine A (1), paspaline (2), paspalinine (3), and penitrem A (4); three tricycloalternarene derivatives: tricycloalternarene 3a (5), tricycloalternarene 1b (6), and tricycloalternarene 2b (7); and two alternariol congeners: djalonensone (8) and alternariol (9). The chemical structures of these metabolites were characterized through a combination of detailed spectroscopic analyses and their comparison with reports from the literature. The inhibitory activities of each isolated compound against four bacteria were evaluated and compounds 5 and 8 displayed moderate activity against the aquaculture pathogenic bacterium Vibrio anguillarum, with inhibition zone diameters of 8 and 9 mm, respectively, at 100 mu g/disk. To the best of our knowledge, this is the first report on the secondary metabolites of mangrove-derived A lternaria tenuissima and also the first report of the isolation of indole-diterpenoids from fungal genus Alternaria. |
关键词 | Endophytic Fungus Alternaria Tenuissima Rhizophora Stylosa Indole-diterpene |
学科领域 | Marine & Freshwater Biology ; Oceanography |
DOI | 10.1007/s00343-013-2106-2 |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Marine & Freshwater Biology ; Oceanography |
WOS类目 | Limnology ; Oceanography |
WOS记录号 | WOS:000316018300024 |
WOS关键词 | PENICILLIUM-PAXILLI ; CHAETOMIUM-GLOBOSUM ; VIBRIO-ANGUILLARUM ; EUROTIUM-RUBRUM ; ALPHA-PYRONE ; TOXINS ; BIOSYNTHESIS ; METABOLITES ; DERIVATIVES ; ANTIFUNGAL |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/16541 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Wang, BG |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
第一作者单位 | 实验海洋生物学重点实验室 |
推荐引用方式 GB/T 7714 | Sun Hong,Gao Shushan,Li Xiaoming,et al. Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2013,31(2):464-470. |
APA | Sun Hong,Gao Shushan,Li Xiaoming,Li Chunshun,Wang Bingui,&Wang, BG.(2013).Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,31(2),464-470. |
MLA | Sun Hong,et al."Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 31.2(2013):464-470. |
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