Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192

doi:10.1007/s00343-013-2106-2

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	Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192
	Sun Hong 1,2; Gao Shushan 1,2; Li Xiaoming 1; Li Chunshun 1; Wang Bingui1 ; Wang, BG
	2013-03-01
发表期刊	CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN	0254-4059
卷号	31 期号:2 页码:464-470
文章类型	Article
摘要	A chemical investigation of the ethyl acetate extract of the fermentation broth of Alternaria tenuissima EN-192, an endophytic fungus obtained from the stems of the marine mangrove plant Rhizophora stylosa, resulted in the isolation of nine known secondary metabolites, including four indole-diterpenoids: penijanthine A (1), paspaline (2), paspalinine (3), and penitrem A (4); three tricycloalternarene derivatives: tricycloalternarene 3a (5), tricycloalternarene 1b (6), and tricycloalternarene 2b (7); and two alternariol congeners: djalonensone (8) and alternariol (9). The chemical structures of these metabolites were characterized through a combination of detailed spectroscopic analyses and their comparison with reports from the literature. The inhibitory activities of each isolated compound against four bacteria were evaluated and compounds 5 and 8 displayed moderate activity against the aquaculture pathogenic bacterium Vibrio anguillarum, with inhibition zone diameters of 8 and 9 mm, respectively, at 100 mu g/disk. To the best of our knowledge, this is the first report on the secondary metabolites of mangrove-derived A lternaria tenuissima and also the first report of the isolation of indole-diterpenoids from fungal genus Alternaria.; A chemical investigation of the ethyl acetate extract of the fermentation broth of Alternaria tenuissima EN-192, an endophytic fungus obtained from the stems of the marine mangrove plant Rhizophora stylosa, resulted in the isolation of nine known secondary metabolites, including four indole-diterpenoids: penijanthine A (1), paspaline (2), paspalinine (3), and penitrem A (4); three tricycloalternarene derivatives: tricycloalternarene 3a (5), tricycloalternarene 1b (6), and tricycloalternarene 2b (7); and two alternariol congeners: djalonensone (8) and alternariol (9). The chemical structures of these metabolites were characterized through a combination of detailed spectroscopic analyses and their comparison with reports from the literature. The inhibitory activities of each isolated compound against four bacteria were evaluated and compounds 5 and 8 displayed moderate activity against the aquaculture pathogenic bacterium Vibrio anguillarum, with inhibition zone diameters of 8 and 9 mm, respectively, at 100 mu g/disk. To the best of our knowledge, this is the first report on the secondary metabolites of mangrove-derived A lternaria tenuissima and also the first report of the isolation of indole-diterpenoids from fungal genus Alternaria.
关键词	Endophytic Fungus Alternaria Tenuissima Rhizophora Stylosa Indole-diterpene
学科领域	Marine & Freshwater Biology ; Oceanography
DOI	10.1007/s00343-013-2106-2
URL	查看原文
收录类别	SCI
语种	英语
WOS研究方向	Marine & Freshwater Biology ; Oceanography
WOS类目	Limnology ; Oceanography
WOS记录号	WOS:000316018300024
WOS关键词	PENICILLIUM-PAXILLI ; CHAETOMIUM-GLOBOSUM ; VIBRIO-ANGUILLARUM ; EUROTIUM-RUBRUM ; ALPHA-PYRONE ; TOXINS ; BIOSYNTHESIS ; METABOLITES ; DERIVATIVES ; ANTIFUNGAL
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/16541
专题	实验海洋生物学重点实验室
通讯作者	Wang, BG
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
第一作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Sun Hong,Gao Shushan,Li Xiaoming,et al. Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2013,31(2):464-470.
APA	Sun Hong,Gao Shushan,Li Xiaoming,Li Chunshun,Wang Bingui,&Wang, BG.(2013).Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,31(2),464-470.
MLA	Sun Hong,et al."Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 31.2(2013):464-470.

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