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Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster
Tang, Xueying1,3; Huang, Baoyu1,2,6; Lin, Siheng1,2; Wang, Wei1,2,5,6; Zhang, Guofan1,2,5,6; Li, Li1,2,4,5,6
2020
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume96Pages:138-140
AbstractMyD88 is a universal adapter protein for the Toll-like receptor/interleukin-1 receptor (TLR/IL-1R) signaling pathway. Since invertebrates are believed to lack MyD88-independent pathways, MyD88 appears more critical in oyster TLR signaling pathway. In the Pacific oyster (Crassostrea gigas), two complete paralogues, named as CgMyD88-1 and CgMyD88-2, have been identified. In the current study, we indicated that CgMyD88-1 and CgMyD88-2 might act synergistically to increase the efficiency of immune signaling by activating NF-kappa B transcription factor. However, we found that upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid [poly (I:C)], CgMyD88-1 and CgMyD88-2 show differences in their response: CgMyD88-1 accumulated as large spots in the cytoplasm, while CgMyD88-2 assembled in the cytoplasm and in the membrane. Our results support the theory that expansion of these immune genes is associated with functional diversity.
KeywordCrassostrea gigas Innate immunity MyD88 Functional diversity
DOI10.1016/j.fsi.2019.10.060
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFD0900304] ; Earmarked Fund for China Agricultural Research System[CARS-49] ; Scientific Research Staring Foundation of Minnan normal university[4206-L21829]
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000509617400016
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation statistics
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/164485
Collection实验海洋生物学重点实验室
Corresponding AuthorLi, Li
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Shandong, Peoples R China
3.Minnan Normal Univ, Dept Biol Sci & Biotechnol, Zhangzhou 363000, Fujian, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Shandong, Peoples R China
5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China
6.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Shandong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Tang, Xueying,Huang, Baoyu,Lin, Siheng,et al. Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster[J]. FISH & SHELLFISH IMMUNOLOGY,2020,96:138-140.
APA Tang, Xueying,Huang, Baoyu,Lin, Siheng,Wang, Wei,Zhang, Guofan,&Li, Li.(2020).Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster.FISH & SHELLFISH IMMUNOLOGY,96,138-140.
MLA Tang, Xueying,et al."Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster".FISH & SHELLFISH IMMUNOLOGY 96(2020):138-140.
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