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Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test
Wang, Shuqin1,2; Qiu, Jiangbing1,2; Zhao, Mingyue1,2; Li, Fangxiao1,2; Yu, Rencheng3; Li, Aifeng1,2
2020-01-15
发表期刊TOXICON
ISSN0041-0101
卷号173页码:39-47
通讯作者Li, Aifeng(lafouc@ouc.edu.cn)
摘要Neurotoxin beta-N-methylamino-L-alanine (BMAA) has been widely detected in diverse aquatic organisms within diffefent ecosystem trophic levels in recent years. It was the goal of this study to investigate the accumulation and tissue distribution of BMAA in marine opossum shrimp (Neomysis awatschensis) and freshwater zebrafish (Danio rerio) in exposure experiments. A T-maze test was tentatively adopted to assess the effects of BMAA on the learning and memory ability of zebrafish. Interestingly, N. awatschensis was testified to be capable of accumulating free soluble BMAA from bathing seawater through a biological filtration pathway (max. 110.6 mu g g(-1) wet weight). BMAA was transferred quickly from viscus to muscle and head tissues of zebrafish after intraperitoneal administration of 16.3 mu g BMAA per individual twice in two weeks. BMAA accumulated mainly as the total soluble form in both experimental organisms. Results do not support the hypothesis that free BMAA molecules can be largely incorporated into protein in aquatic animals. Behavior of zebrafish in the T-maze test demonstrated that the short-term learning and memory ability was negatively impacted to some degree after three-days exposure to BMAA. Moreover, on Day 3, certain individual zebrafish exhibited freezing and loitering behavior. However, further investigation will be required to discern the long-term effects of BMAA on animals in order to evaluate the risk of BMAA exposure to human health.
关键词beta-N-mothylamino-L-alanine (BMAA) Toxin accumulation Opossum shrimp Zebrafish T-maze test
DOI10.1016/j.toxicon.2019.11.005
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[41676093] ; Fundamental Research Funds for the Central Universities, China[201841003] ; National Natural Science Foundation of China[41676093] ; Fundamental Research Funds for the Central Universities, China[201841003]
WOS研究方向Pharmacology & Pharmacy ; Toxicology
WOS类目Pharmacology & Pharmacy ; Toxicology
WOS记录号WOS:000508739100005
出版者PERGAMON-ELSEVIER SCIENCE LTD
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/164413
专题海洋生态与环境科学重点实验室
通讯作者Li, Aifeng
作者单位1.Ocean Univ China, Coll Environm Sci & Engn, Qingdao 266100, Peoples R China
2.Ocean Univ China, Key Lab Marine Environm & Ecol, Minist Educ, Qingdao 266100, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
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Wang, Shuqin,Qiu, Jiangbing,Zhao, Mingyue,et al. Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test[J]. TOXICON,2020,173:39-47.
APA Wang, Shuqin,Qiu, Jiangbing,Zhao, Mingyue,Li, Fangxiao,Yu, Rencheng,&Li, Aifeng.(2020).Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test.TOXICON,173,39-47.
MLA Wang, Shuqin,et al."Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test".TOXICON 173(2020):39-47.
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