Institutional Repository of Key Laboratory of Marine Ecology & Environmental Sciences, CAS
| Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test | |
| Wang, Shuqin1,2; Qiu, Jiangbing1,2; Zhao, Mingyue1,2; Li, Fangxiao1,2; Yu, Rencheng3; Li, Aifeng1,2 | |
| 2020-01-15 | |
| Source Publication | TOXICON
 |
| ISSN | 0041-0101 |
| Volume | 173Pages:39-47 |
| Corresponding Author | Li, Aifeng(lafouc@ouc.edu.cn) |
| Abstract | Neurotoxin beta-N-methylamino-L-alanine (BMAA) has been widely detected in diverse aquatic organisms within diffefent ecosystem trophic levels in recent years. It was the goal of this study to investigate the accumulation and tissue distribution of BMAA in marine opossum shrimp (Neomysis awatschensis) and freshwater zebrafish (Danio rerio) in exposure experiments. A T-maze test was tentatively adopted to assess the effects of BMAA on the learning and memory ability of zebrafish. Interestingly, N. awatschensis was testified to be capable of accumulating free soluble BMAA from bathing seawater through a biological filtration pathway (max. 110.6 mu g g(-1) wet weight). BMAA was transferred quickly from viscus to muscle and head tissues of zebrafish after intraperitoneal administration of 16.3 mu g BMAA per individual twice in two weeks. BMAA accumulated mainly as the total soluble form in both experimental organisms. Results do not support the hypothesis that free BMAA molecules can be largely incorporated into protein in aquatic animals. Behavior of zebrafish in the T-maze test demonstrated that the short-term learning and memory ability was negatively impacted to some degree after three-days exposure to BMAA. Moreover, on Day 3, certain individual zebrafish exhibited freezing and loitering behavior. However, further investigation will be required to discern the long-term effects of BMAA on animals in order to evaluate the risk of BMAA exposure to human health. |
| Keyword | beta-N-mothylamino-L-alanine (BMAA) Toxin accumulation Opossum shrimp Zebrafish T-maze test |
| DOI | 10.1016/j.toxicon.2019.11.005 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[41676093] ; Fundamental Research Funds for the Central Universities, China[201841003] ; National Natural Science Foundation of China[41676093] ; Fundamental Research Funds for the Central Universities, China[201841003] |
| WOS Research Area | Pharmacology & Pharmacy ; Toxicology |
| WOS Subject | Pharmacology & Pharmacy ; Toxicology |
| WOS ID | WOS:000508739100005 |
| Publisher | PERGAMON-ELSEVIER SCIENCE LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/164413 |
| Collection | 海洋生态与环境科学重点实验室 |
| Corresponding Author | Li, Aifeng |
| Affiliation | 1.Ocean Univ China, Coll Environm Sci & Engn, Qingdao 266100, Peoples R China 2.Ocean Univ China, Key Lab Marine Environm & Ecol, Minist Educ, Qingdao 266100, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Shuqin,Qiu, Jiangbing,Zhao, Mingyue,et al. Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test[J]. TOXICON,2020,173:39-47. |
| APA | Wang, Shuqin,Qiu, Jiangbing,Zhao, Mingyue,Li, Fangxiao,Yu, Rencheng,&Li, Aifeng.(2020).Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test.TOXICON,173,39-47. |
| MLA | Wang, Shuqin,et al."Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test".TOXICON 173(2020):39-47. |
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