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Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test
Wang, Shuqin1,2; Qiu, Jiangbing1,2; Zhao, Mingyue1,2; Li, Fangxiao1,2; Yu, Rencheng3; Li, Aifeng1,2
2020-01-15
Source PublicationTOXICON
ISSN0041-0101
Volume173Pages:39-47
Corresponding AuthorLi, Aifeng(lafouc@ouc.edu.cn)
AbstractNeurotoxin beta-N-methylamino-L-alanine (BMAA) has been widely detected in diverse aquatic organisms within diffefent ecosystem trophic levels in recent years. It was the goal of this study to investigate the accumulation and tissue distribution of BMAA in marine opossum shrimp (Neomysis awatschensis) and freshwater zebrafish (Danio rerio) in exposure experiments. A T-maze test was tentatively adopted to assess the effects of BMAA on the learning and memory ability of zebrafish. Interestingly, N. awatschensis was testified to be capable of accumulating free soluble BMAA from bathing seawater through a biological filtration pathway (max. 110.6 mu g g(-1) wet weight). BMAA was transferred quickly from viscus to muscle and head tissues of zebrafish after intraperitoneal administration of 16.3 mu g BMAA per individual twice in two weeks. BMAA accumulated mainly as the total soluble form in both experimental organisms. Results do not support the hypothesis that free BMAA molecules can be largely incorporated into protein in aquatic animals. Behavior of zebrafish in the T-maze test demonstrated that the short-term learning and memory ability was negatively impacted to some degree after three-days exposure to BMAA. Moreover, on Day 3, certain individual zebrafish exhibited freezing and loitering behavior. However, further investigation will be required to discern the long-term effects of BMAA on animals in order to evaluate the risk of BMAA exposure to human health.
Keywordbeta-N-mothylamino-L-alanine (BMAA) Toxin accumulation Opossum shrimp Zebrafish T-maze test
DOI10.1016/j.toxicon.2019.11.005
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41676093] ; Fundamental Research Funds for the Central Universities, China[201841003]
WOS Research AreaPharmacology & Pharmacy ; Toxicology
WOS SubjectPharmacology & Pharmacy ; Toxicology
WOS IDWOS:000508739100005
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/164413
Collection海洋生态与环境科学重点实验室
Corresponding AuthorLi, Aifeng
Affiliation1.Ocean Univ China, Coll Environm Sci & Engn, Qingdao 266100, Peoples R China
2.Ocean Univ China, Key Lab Marine Environm & Ecol, Minist Educ, Qingdao 266100, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Wang, Shuqin,Qiu, Jiangbing,Zhao, Mingyue,et al. Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test[J]. TOXICON,2020,173:39-47.
APA Wang, Shuqin,Qiu, Jiangbing,Zhao, Mingyue,Li, Fangxiao,Yu, Rencheng,&Li, Aifeng.(2020).Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test.TOXICON,173,39-47.
MLA Wang, Shuqin,et al."Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test".TOXICON 173(2020):39-47.
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