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Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs
Huan, Pin1,2,3; Wang, Qian1,3; Tan, Sujian1; Liu, Baozhong1,2,3
2020-01-07
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
Volume117Issue:1Pages:503-512
Corresponding AuthorLiu, Baozhong(bzliu@qdio.ac.cn)
AbstractIn contrast to the Hox genes in arthropods and vertebrates, those in molluscs show diverse expression patterns with differences reported among lineages. Here, we investigate 2 phylogenetically distant molluscs, a gastropod and a polyplacophoran, and show that the Hox expression in both species can be divided into 2 categories. The Hox expression in the ventral ectoderm generally shows a canonical staggered pattern comparable to the patterns of other bilaterians and likely contributes to ventral patterning, such as neurogenesis. The other category of Hox expression on the dorsal side is strongly correlated with shell formation and exhibits lineage-specific characteristics in each class of mollusc. This generalized model of decoupled dorsoventral Hox expression is compatible with known Hox expression data from other molluscan lineages and may represent a key characteristic of molluscan Hox expression. These results support the concept of widespread staggered Hox expression in Mollusca and reveal aspects that may be related to the evolutionary diversification of molluscs. We propose that dorsoventral decoupling of Hox expression allowed lineage-specific dorsal and ventral patterning, which may have facilitated the evolution of diverse body plans in different molluscan lineages.
KeywordHox mollusc dorsoventral decoupling staggered expression shell
DOI10.1073/pnas.1907328117
Indexed BySCI
Language英语
Funding ProjectNational Key Research & Development Program of China[2018YFD0900104] ; Marine Science & Technology Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)[2018SDKJ03021] ; China Agriculture Research System[CARS-49] ; National Natural Science Foundation of China[41776157]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000506001200073
PublisherNATL ACAD SCIENCES
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/164149
Collection实验海洋生物学重点实验室
Corresponding AuthorLiu, Baozhong
Affiliation1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266000, Peoples R China
3.Univ Chinese Acad Sci, Coll Adv Agr Sci, Beijing 100039, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Huan, Pin,Wang, Qian,Tan, Sujian,et al. Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2020,117(1):503-512.
APA Huan, Pin,Wang, Qian,Tan, Sujian,&Liu, Baozhong.(2020).Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,117(1),503-512.
MLA Huan, Pin,et al."Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117.1(2020):503-512.
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