Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs | |
Huan, Pin1,2,3; Wang, Qian1,3 ; Tan, Sujian1; Liu, Baozhong1,2,3
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| 2020-01-07 | |
| Source Publication | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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| ISSN | 0027-8424 |
| Volume | 117Issue:1Pages:503-512 |
| Corresponding Author | Liu, Baozhong(bzliu@qdio.ac.cn) |
| Abstract | In contrast to the Hox genes in arthropods and vertebrates, those in molluscs show diverse expression patterns with differences reported among lineages. Here, we investigate 2 phylogenetically distant molluscs, a gastropod and a polyplacophoran, and show that the Hox expression in both species can be divided into 2 categories. The Hox expression in the ventral ectoderm generally shows a canonical staggered pattern comparable to the patterns of other bilaterians and likely contributes to ventral patterning, such as neurogenesis. The other category of Hox expression on the dorsal side is strongly correlated with shell formation and exhibits lineage-specific characteristics in each class of mollusc. This generalized model of decoupled dorsoventral Hox expression is compatible with known Hox expression data from other molluscan lineages and may represent a key characteristic of molluscan Hox expression. These results support the concept of widespread staggered Hox expression in Mollusca and reveal aspects that may be related to the evolutionary diversification of molluscs. We propose that dorsoventral decoupling of Hox expression allowed lineage-specific dorsal and ventral patterning, which may have facilitated the evolution of diverse body plans in different molluscan lineages. |
| Keyword | Hox mollusc dorsoventral decoupling staggered expression shell |
| DOI | 10.1073/pnas.1907328117 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research & Development Program of China[2018YFD0900104] ; Marine Science & Technology Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)[2018SDKJ03021] ; China Agriculture Research System[CARS-49] ; National Natural Science Foundation of China[41776157] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000506001200073 |
| Publisher | NATL ACAD SCIENCES |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/164149 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Liu, Baozhong |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266000, Peoples R China 3.Univ Chinese Acad Sci, Coll Adv Agr Sci, Beijing 100039, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Huan, Pin,Wang, Qian,Tan, Sujian,et al. Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2020,117(1):503-512. |
| APA | Huan, Pin,Wang, Qian,Tan, Sujian,&Liu, Baozhong.(2020).Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,117(1),503-512. |
| MLA | Huan, Pin,et al."Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117.1(2020):503-512. |
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