Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs

doi:10.1073/pnas.1907328117

IOCAS-IR > 实验海洋生物学重点实验室

	Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs
	Huan, Pin 1,2,3; Wang, Qian1,3 ; Tan, Sujian 1; Liu, Baozhong1,2,3
	2020-01-07
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
卷号	117 期号:1 页码:503-512
通讯作者	Liu, Baozhong(bzliu@qdio.ac.cn)
摘要	In contrast to the Hox genes in arthropods and vertebrates, those in molluscs show diverse expression patterns with differences reported among lineages. Here, we investigate 2 phylogenetically distant molluscs, a gastropod and a polyplacophoran, and show that the Hox expression in both species can be divided into 2 categories. The Hox expression in the ventral ectoderm generally shows a canonical staggered pattern comparable to the patterns of other bilaterians and likely contributes to ventral patterning, such as neurogenesis. The other category of Hox expression on the dorsal side is strongly correlated with shell formation and exhibits lineage-specific characteristics in each class of mollusc. This generalized model of decoupled dorsoventral Hox expression is compatible with known Hox expression data from other molluscan lineages and may represent a key characteristic of molluscan Hox expression. These results support the concept of widespread staggered Hox expression in Mollusca and reveal aspects that may be related to the evolutionary diversification of molluscs. We propose that dorsoventral decoupling of Hox expression allowed lineage-specific dorsal and ventral patterning, which may have facilitated the evolution of diverse body plans in different molluscan lineages.
关键词	Hox mollusc dorsoventral decoupling staggered expression shell
DOI	10.1073/pnas.1907328117
收录类别	SCI
语种	英语
资助项目	National Key Research & Development Program of China[2018YFD0900104] ; Marine Science & Technology Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)[2018SDKJ03021] ; China Agriculture Research System[CARS-49] ; National Natural Science Foundation of China[41776157] ; National Key Research & Development Program of China[2018YFD0900104] ; Marine Science & Technology Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)[2018SDKJ03021] ; China Agriculture Research System[CARS-49] ; National Natural Science Foundation of China[41776157]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000506001200073
出版者	NATL ACAD SCIENCES
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/164149
专题	实验海洋生物学重点实验室
通讯作者	Liu, Baozhong
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266000, Peoples R China 3.Univ Chinese Acad Sci, Coll Adv Agr Sci, Beijing 100039, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Huan, Pin,Wang, Qian,Tan, Sujian,et al. Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2020,117(1):503-512.
APA	Huan, Pin,Wang, Qian,Tan, Sujian,&Liu, Baozhong.(2020).Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,117(1),503-512.
MLA	Huan, Pin,et al."Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117.1(2020):503-512.

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